Western Blot (WB)
(Anti-Stra8 antibody, MBS175253, Western blottingLane 1: A231 Cell LysateLane 2: JURKAT Cell LysateLane 3: HT1080 Cell LysateLane 4: SCG Cell Lysate )
Rabbit anti-Human Stra8 Polyclonal Antibody | anti-STRA8 antibody
Anti-Stra8 antibody
Western Blot (WB)
(Anti-Stra8 antibody, MBS175253, Western blottingLane 1: A231 Cell LysateLane 2: JURKAT Cell LysateLane 3: HT1080 Cell LysateLane 4: SCG Cell Lysate )
Western Blot (WB)
(Anti-Stra8 antibody, MBS175253, Western blottingLane 1: A231 Cell LysateLane 2: JURKAT Cell LysateLane 3: HT1080 Cell LysateLane 4: SCG Cell Lysate )
Background: Stra8, stimulated by retinoic acid 8, is expressed in embryonic ovaries just before meiotic initiation, whereas in testis it is expressed after birth. The STRA8 gene contains 9 exons. And this gene is mapped to chromosome 7q31. Retinoic acid(RA) signaling was required for Stra8 expression, and therefore initiation of meiosis, in embryonic mouse ovaries. RA was sufficient to induce Stra8 expression in embryonic testis. Cyp26-mediated RA metabolism was responsible for delaying Stra8 expression in embryonic testis. Since RA signaling regulated Stra8 expression in both embryonic ovaries and adult testis, it was said this portion of the meiotic initiation pathway may be identical in both sexes.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a retinoic acid-responsive protein. A homologous protein in mouse has been shown to be involved in the regulation of meiotic initiation in both spermatogenesis and oogenesis, though feature differences between the mouse and human proteins suggest that these homologs are not entirely functionally equivalent. It is thought that this gene may play a role in spermatogenesis in humans. [provided by RefSeq, Nov 2010]
Uniprot Description
STRA8: Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, required for premeiotic DNA replication and subsequent events in meiotic prophase.
Chromosomal Location of Human Ortholog: 7q33
Cellular Component: cytoplasm; nucleus
Molecular Function: protein dimerization activity
Biological Process: fertilization; meiotic cell cycle DNA replication checkpoint; ovarian follicle development; meiotic chromosome condensation; meiotic recombination; synapsis; meiotic DNA double-strand break formation; spermatogenesis; regulation of organ growth; female meiosis sister chromatid cohesion; DNA replication; oocyte development
Research Articles on STRA8
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Product Notes
The STRA8 stra8 (Catalog #AAA175253) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Stra8 antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Stra8 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the STRA8 stra8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Stra8, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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