Rabbit SSTR3 Polyclonal Antibody | anti-SSTR3 antibody

SSTR3 Polyclonal Antibody

Cat. Num. AAA2517985

• Gene Names: SSTR3; SS3R; SS3-R; SS-3-R; SSR-28
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: SSTR3; Polyclonal Antibody; SSTR3 Polyclonal Antibody; anti-SSTR3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 1.3mg/mL (varies by lot)
• Sequence Length: 418

• Applicable Applications for anti-SSTR3 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:25-1:100
• Immunogen: Synthetic peptide of human SSTR3
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human breast cancer tissue using SSTR3 Polyclonal Antibody at dilution 1:40)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using SSTR3 Polyclonal Antibody at dilution 1:40)

Related Product Information for anti-SSTR3 antibody

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR3 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in brain and pancreatic islets. SSTR3 is functionally coupled to adenylyl cyclase.

Product Categories/Family for anti-SSTR3 antibody

Cell Biology

NCBI and Uniprot Product Information

• NCBI GI #: 522838250
• NCBI GeneID: 6753
• NCBI Accession #: NP_001265616.1
• NCBI GenBank Nucleotide #: NM_001278687.2
• Molecular Weight: 45,847 Da
• NCBI Official Full Name: somatostatin receptor type 3
• NCBI Official Synonym Full Names: somatostatin receptor 3
• NCBI Official Symbol: SSTR3
• NCBI Official Synonym Symbols: SS3R; SS3-R; SS-3-R; SSR-28
• NCBI Protein Information: somatostatin receptor type 3
• UniProt Protein Name: Somatostatin receptor type 3
• Protein Family: Somatostatin receptor
• UniProt Gene Name: SSTR3
• UniProt Synonym Gene Names: SS-3-R; SS3-R; SS3R
• UniProt Entry Name: SSR3_HUMAN

NCBI Description

This gene encodes a member of the somatostatin receptor protein family. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This protein is functionally coupled to adenylyl cyclase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Description

SSTR3: Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: neuron projection; nonmotile primary cilium; integral to plasma membrane; cytoplasm; plasma membrane

Molecular Function: neuropeptide binding; protein binding; somatostatin receptor activity

Biological Process: response to starvation; negative regulation of cell proliferation; G-protein signaling, coupled to cyclic nucleotide second messenger; synaptic transmission; cell-cell signaling; induction of apoptosis by hormones; neuropeptide signaling pathway; organelle organization and biogenesis; forebrain development; cerebellum development; spermatogenesis; regulation of insulin secretion