Rabbit anti-Human SPOCK1 Polyclonal Antibody | anti-SPOCK1 antibody

SPOCK1, NT (SPOCK1, SPOCK, TIC1, TICN1, Testican-1, Protein SPOCK) (Biotin)

Cat. Num. AAA6350717

• Gene Names: SPOCK1; TIC1; SPOCK; TESTICAN
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SPOCK1; Polyclonal Antibody; NT (SPOCK1; SPOCK; TIC1; TICN1; Testican-1; Protein SPOCK) (Biotin); Protein SPOCK; anti-SPOCK1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human SPOCK1.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-SPOCK1 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 32-61 in the N-terminal region of human SPOCK1, UniProt Accession #NP_004589.1; Q08629; Q62288. Species sequence homology: mouse
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in MDA-MB453 cell line lysates (35ug/lane) usingMBS6007782. This demonstrates the SPOCK1 antibody detected the SPOCK1 protein (arrow).)

Related Product Information for anti-SPOCK1 antibody

This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin-and heparan-sulfate chains. The protein's function is unknown, although similarity to thyropin-type cysteine protease-inhibitors suggests its function may be related to protease inhibition.

Product Categories/Family for anti-SPOCK1 antibody

Antibodies; Proteins

References

1. Rose, J. Phd, et al. Mol. Med. (2010). 2. Liu, Y.Z., et al. PLoS Genet. 5 (3), E1000420 (2009). 3. Prenzel, K.L., et al. Oncol. Rep. 15(5):1397-1401 (2006). 4. Schmutz, J., et al. Nature 431(7006):268-274 (2004). 5. Nakada, M., et al. Cancer Res. 63(12):3364-3369 (2003).

NCBI and Uniprot Product Information

• NCBI GI #: 4759164
• NCBI GeneID: 6695
• NCBI Accession #: NP_004589.1
• NCBI GenBank Nucleotide #: NM_004598.3
• UniProt Accession #: Q08629; Q62288
• Molecular Weight: 47.8 kDa
• NCBI Official Full Name: testican-1
• NCBI Official Synonym Full Names: SPARC/osteonectin, cwcv and kazal like domains proteoglycan 1
• NCBI Official Symbol: SPOCK1
• NCBI Official Synonym Symbols: TIC1; SPOCK; TESTICAN
• NCBI Protein Information: testican-1
• UniProt Protein Name: Testican-1
• Protein Family: Testican
• UniProt Gene Name: SPOCK1
• UniProt Synonym Gene Names: SPOCK; TIC1; TICN1

NCBI Description

This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is unknown, although similarity to thyropin-type cysteine protease-inhibitors suggests its function may be related to protease inhibition. [provided by RefSeq, Jul 2008]

Uniprot Description

SPOCK1: May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system.

Protein type: Cell adhesion; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q31.2

Cellular Component: cytoplasm; extracellular space; neuromuscular junction; sarcoplasm

Molecular Function: calcium ion binding; cysteine protease inhibitor activity; metalloendopeptidase inhibitor activity

Biological Process: central nervous system neuron differentiation; neurogenesis; neuron migration