Rabbit RTN3 Antibody | anti-RTN3 antibody

RTN3 Rabbit Polyclonal

Cat. Num. AAA7603756

• Gene Names: Rtn3; RTN3-A1
• Reactivity: Human, Mouse, Rat; other species are not tested.
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunoprecipitation
• Purity: >95% as determined by SDS-PAGE, Immunogen affinity purified
• Synonyms: RTN3; RTN3 Rabbit Polyclonal; ASYIP; HAP; NSP like protein 2; NSP like protein II; NSPL2; NSPLII; reticulon 3; RTN3 A1; anti-RTN3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat; other species are not tested.
• Isotype: IgG
• Specificity: Please decide the specificity by homology.
• Purity/Purification: >95% as determined by SDS-PAGE, Immunogen affinity purified
• Form/Format: Liquid; PBS with 0.02% sodium azide and 50% glycerol pH 7.3

• Applicable Applications for anti-RTN3 antibody: ELISA, Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
• Application Notes: Recommended dilution: WB : 1:500-1:3000, IP : 1:200-1:1000, IHC : 1:20-1:200
• Immunogen: reticulon 3
• Preparation and Storage: Store at -20°C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human gliomas using MBS7603756 (RTN3 antibody) at dilution of 1:50)

Immunoprecipitation (IP)

(IP Result of anti-RTN3 (IP: MBS7603756, 4ug; Detection: MBS7603756 1:400) with HeLa cells lysate 2000ug.)

Western Blot (WB)

(HeLa cells were subjected to SDS PAGE followed by western blot with MBS7603756 (RTN3 antibody) at dilution of 1:500)

Related Product Information for anti-RTN3 antibody

May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671).

NCBI and Uniprot Product Information

• NCBI GI #: 407339785
• NCBI GeneID: 20168
• NCBI Accession #: NP_001258416.1
• NCBI GenBank Nucleotide #: NM_001271487.1
• UniProt Accession #: O95197; Q3UF62; Q544J1; Q68FE4; Q6IM69; Q6R8K6; Q6R8K7; Q6T929; Q8C6D5; Q8CCU2; Q9ES97
• Molecular Weight: Calculated MW: 24 kDa, 113 kDa
• NCBI Official Full Name: reticulon-3 isoform 6
• NCBI Official Synonym Full Names: reticulon 3
• NCBI Official Symbol: Rtn3
• NCBI Official Synonym Symbols: RTN3-A1
• NCBI Protein Information: reticulon-3
• UniProt Protein Name: Reticulon-3
• Protein Family: Reticulon
• UniProt Gene Name: Rtn3
• UniProt Entry Name: RTN3_MOUSE

Uniprot Description

RTN3: May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Endoplasmic reticulum

Cellular Component: endomembrane system; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; integral to membrane; membrane

Molecular Function: protein binding

Biological Process: apoptosis; transport; vesicle-mediated transport