Western Blot (WB)
(SARS2 polyclonal antibody. Western Blot analysis of SARS2 expression in human liver.)
Mouse anti-Human SARS2 Polyclonal Antibody | anti-SARS2 antibody
SARS2 (Seryl-tRNA Synthetase, Mitochondrial, Seryl-tRNA(Ser/Sec) Synthetase, Serine-tRNA Ligase, SerRS, SerRSmt, SARSM, FLJ20450)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Western Blot (WB)
(SARS2 polyclonal antibody. Western Blot analysis of SARS2 expression in human liver.)
Western Blot (WB)
(SARS2 polyclonal antibody. Western Blot analysis of SARS2 expression in human liver.)
Western Blot (WB)
(SARS2 polyclonal antibody. Western Blot analysis of SARS2 expression in HeLa.)
Western Blot (WB)
(SARS2 polyclonal antibody. Western Blot analysis of SARS2 expression in HeLa.)
Western Blot (WB)
(Western Blot analysis of SARS2 expression in transfected 293T cell line by SARS2 polyclonal antibody. Lane 1: SARS2 transfected lysate (56.98kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of SARS2 expression in transfected 293T cell line by SARS2 polyclonal antibody. Lane 1: SARS2 transfected lysate (56.98kD). Lane 2: Non-transfected lysate.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
Uniprot Description
SARS2: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). Defects in SARS2 are the cause of hyperuricemia pulmonary hypertension renal failure and alkalosis (HUPRA). HUPRA is a multisystem disorder characterized by onset in infancy of progressive renal failure leading to electrolyte imbalances, metabolic alkalosis, pulmonary hypertension, hypotonia, and delayed development. Affected individuals are born prematurely. Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ligase; EC 6.1.1.11; Mitochondrial; Translation
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: mitochondrion; mitochondrial matrix
Molecular Function: serine-tRNA ligase activity; ATP binding
Biological Process: seryl-tRNA aminoacylation; tRNA aminoacylation for protein translation; gene expression
Disease: Hyperuricemia, Pulmonary Hypertension, Renal Failure, And Alkalosis
Research Articles on SARS2
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Product Notes
The SARS2 sars2 (Catalog #AAA642288) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The SARS2 (Seryl-tRNA Synthetase, Mitochondrial, Seryl-tRNA(Ser/Sec) Synthetase, Serine-tRNA Ligase, SerRS, SerRSmt, SARSM, FLJ20450) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SARS2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Researchers should empirically determine the suitability of the SARS2 sars2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MAASMARRLW PLLTRRGFRP RGGCISNDSP RRSFTTEKRN RNLLYEYARE GYSALPQLDI ERFCACPEEA AHALELRKGE LRSADLPAII STWQELRQLQ EQIRSLEEEK AAVTEAVRAL LANQDSGEVQ QDPKYQGLRA RGREIRKELV HLYPREAQLE EQFYLQALKL PNQTHPDVPV GDESQARVLH MVGDKPVFSF QPRGHLEIGE KLDIIRQKRL SHVSGHRSYY LRGAGALLQH GLVNFTFNKL LRRGFTPMTV PDLLRGAVFE GCGMTPNANP SQIYNIDPAR FKDLNLAGTA EVGLAGYFMD HTVAFRDLPV RMVCSSTCYR AETNTGQEPR GLYRVHHFTK VEMFGVTGPG LEQSSQLLEE FLSLQMEILT ELGLHFRVLD MPTQELGLPA YRKFDIEAWM PGRGRFGEVT SASNCTDFQS RRLHIMFQTE AGELQFAHTV NATACAVPRL LIALLESNQQ KDGSVLVPPA LQSYLGTDRI TAPTHVPLQY IGPNQPRKPG LPGQPAVS. It is sometimes possible for the material contained within the vial of "SARS2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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