Rabbit anti-Human SLC6A14 Polyclonal Antibody | anti-SLC6A14 antibody

SLC6A14, CT (SLC6A14, Sodium-and chloride-dependent neutral and basic amino acid transporter B(0+), Amino acid transporter ATB0+, Solute carrier family 6 member 14) (Biotin)

Cat. Num. AAA6348519

• Gene Names: SLC6A14; BMIQ11
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA, Western Blot
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: SLC6A14; Polyclonal Antibody; CT (SLC6A14; Sodium-and chloride-dependent neutral and basic amino acid transporter B(0+); Amino acid transporter ATB0+; Solute carrier family 6 member 14) (Biotin); Solute carrier family 6 member 14; anti-SLC6A14 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human SLC6A14.
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-SLC6A14 antibody: Immunohistochemistry (IHC) Paraffin, ELISA (EIA), Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids aa601-631 in the C-terminal region of human SLC6A14. Swiss/UniProt Accession: Q9UN76
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in HL-60 cell line lysates (35ug/lane) usingMBS643590. This demonstrates MBS643590 detected the SLC6A14 protein (arrow).)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis in formalin fixed and paraffin embedded human esophageal carcinoma using MBS643960 followed by peroxidase conjugation of the secondary antibody and DAB staining.)

Product Categories/Family for anti-SLC6A14 antibody

Antibodies; Ion Channel

References

1. Bailey, S.D., et al. Diabetes Care (2010) In press 2. Corpeleijn, E., et al. Obesity (Silver Spring) 18(7):1369-1377(2010). 3. Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009). 4. Anderson, C.M., et al. J. Physiol. (Lond.) 586 (PT 17):4061-4067 (2008). 5. Eriksson, A., et al. BMC Gastroenterol 8:34 (2008).

NCBI and Uniprot Product Information

• NCBI GI #: 6005715
• NCBI GeneID: 11254
• NCBI Accession #: NP_009162.1
• NCBI GenBank Nucleotide #: NM_007231.4
• UniProt Accession #: Q9UN76; Q5H942
• Molecular Weight: 72,153 Da
• NCBI Official Full Name: sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
• NCBI Official Synonym Full Names: solute carrier family 6 (amino acid transporter), member 14
• NCBI Official Symbol: SLC6A14
• NCBI Official Synonym Symbols: BMIQ11
• NCBI Protein Information: sodium- and chloride-dependent neutral and basic amino acid transporter B(0+); sodium- and chloride-dependent neutral and basic amino acid transporter B(0+); amino acid transporter B0+; amino acid transporter ATB0+; solute carrier family 6 (neurotransmitt
• UniProt Protein Name: Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
• Protein Family: Sodium- and chloride-dependent neutral and basic amino acid transporter
• UniProt Gene Name: SLC6A14
• UniProt Entry Name: S6A14_HUMAN

NCBI Description

This gene encodes a member of the solute carrier family 6. Members of this family are sodium and chloride dependent neurotransmitter transporters. The encoded protein transports both neutral and cationic amino acids. This protein may also function as a beta-alanine carrier. Mutations in this gene may be associated with X-linked obesity. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, May 2010]

Uniprot Description

SLC6A14: Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner. Genetic variations in SLC6A14 may be associated with obesity in some populations, as shown by significant differences in allele frequencies between obese and non-obese individuals. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A14 subfamily.

Protein type: Transporter; Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq23

Cellular Component: brush border membrane; integral to membrane; plasma membrane; vesicle

Molecular Function: neurotransmitter:sodium symporter activity; amino acid transmembrane transporter activity

Biological Process: amino acid metabolic process; amino acid transport; neurotransmitter transport; transport; response to toxin; ion transport; transmembrane transport

Disease: Body Mass Index Quantitative Trait Locus 11