Rabbit HDAC11 Polyclonal Antibody | anti-HDAC11 antibody

Anti-HDAC11 Antibody, Rabbit Polyclonal

Cat. Num. AAA8100691

• Gene Names: HDAC11; HD11
• Reactivity: Human; Predicted to React with: Mouse (Species predicted to react based on 100% sequence homology)
• Applications: Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: HDAC11; Polyclonal Antibody; Anti-HDAC11 Antibody; Rabbit Polyclonal; HDAC11 Antibody; Rabbit PAb; Antigen Affinity Purified; histone deacetylase 11; Anti-HD11 Antibody; anti-HDAC11 antibody

• Host: Rabbit
• Reactivity: Human; Predicted to React with: Mouse (Species predicted to react based on 100% sequence homology)
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human HDAC11
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-HDAC11 antibody: Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: IHC-P: 1:250-1:1000
• Immunogen: A synthetic peptide corresponding to the N-terminus of the Human HDAC11
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the Human HDAC11, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining of human HDAC11 in human testis with rabbit polyclonal antibody (1:500, formalin-fixed paraffin embedded sections).)

Immunohistochemistry (IHC)

(Immunochemical staining of human HDAC11 in human breast carcinoma with rabbit polyclonal antibody (1:500, formalin-fixed paraffin embedded sections).)

Related Product Information for anti-HDAC11 antibody

Histone deacetylases (HDACs) are enzymes that regulate protein functions by catalyzing the removal of acetyl and acyl groups from lysine residues, which play pivotal roles in governing cell behaviors. HDAC11 knockout mice are resistant to high-fat diet-induced obesity and metabolic syndrome, suggesting that HDAC11 functions as a crucial metabolic regulator. HDAC11 is a novel regulator of obesity, with potentially important implications for obesity-related disease treatment. HDAC11 has therapeutic potential for treating diabetes mellitus-associated cardiac injury. Histone deacetylases (HDACs) are involved in multiple physical and pathological processes in classical Hodgkin lymphoma (cHL). HDAC11 was initially identified as a negative regulator of the well-known anti-inflammatory cytokine IL-10.

Product Categories/Family for anti-HDAC11 antibody

Notch Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 217272877
• NCBI GeneID: 79885
• NCBI Accession #: NP_079103.2
• NCBI GenBank Nucleotide #: NM_024827.3
• UniProt Accession #: Q96DB2; Q9H6I7; Q9H6X3; Q9NTC9; B4DDK1
• Molecular Weight: 33,124 Da
• NCBI Official Full Name: histone deacetylase 11 isoform 1
• NCBI Official Synonym Full Names: histone deacetylase 11
• NCBI Official Symbol: HDAC11
• NCBI Official Synonym Symbols: HD11
• NCBI Protein Information: histone deacetylase 11
• UniProt Protein Name: Histone deacetylase 11
• Protein Family: Histone deacetylase
• UniProt Gene Name: HDAC11
• UniProt Synonym Gene Names: HD11

NCBI Description

This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009]

Uniprot Description

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.