EXOSC4 recombinant protein

EXOSC4, 1-245aa, Human, His tag, E Coli (Denatured)

Cat. Num. AAA204902

• Gene Names: EXOSC4; SKI6; p12A; RRP41; Ski6p; RRP41A; Rrp41p; hRrp41p
• Applications: SDS-Page
• Purity: > 85% by SDS-PAGE
• Synonyms: EXOSC4; 1-245aa; Human; His tag; E Coli (Denatured); Exosome complex component RRP41; hRrp41p; p12A; RRP41; RRP41A; Rrp41p; SKI6; Ski6p; EXOSC4 recombinant protein

• Host: E Coli
• Purity/Purification: > 85% by SDS-PAGE
• Form/Format: Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol 0.4M urea
• Concentration: 0.5 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSMAGLELL SDQGYRVDGR RAGELRKIQA RMGVFAQADG SAYIEQGNTK ALAVVYGPHE IRGSRARALP DRALVNCQYS SATFSTGERK RRPHGDRKSC EMGLQLRQTF EAAILTQLHP RSQIDIYVQV LQADGGTYAA CVNAATLAVL DAGIPMRDFV CACSAGFVDG TALADLSHVE EAAGGPQLAL ALLPASGQIA LLEMDARLHE DHLERVLEAA AQAARDVHTL LDRVVRQHVR EASILLGD
• Sequence Length: 245

• Applicable Applications for EXOSC4 recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for EXOSC4 recombinant protein

EXOSC4, also known as fetuin-A, belongs to the fetuin class of plasma binding proteins. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. It is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has been postulated that it participates in the development of the tissues. It forms soluble complexes with calcium and phosphate and thus is a carrier of otherwise insoluble calcium phosphate. Recombinant human EXOSC4 protein, fused to His-tag at N-terminus, was expressed in E Coli.

Product Categories/Family for EXOSC4 recombinant protein

Epigenomics

References

Osawa M. et al. (1997) Gene. 196:121-125.; Rizzu P. et al. (1995) Cytogenet Cell Genet.. 70:26-28.;

NCBI and Uniprot Product Information

• NCBI GI #: 9506689
• NCBI GeneID: 54512
• NCBI Accession #: NP_061910
• NCBI GenBank Nucleotide #: NM_019037.2
• UniProt Accession #: Q9NPD3
• Molecular Weight: 28.8 kDa (268aa)
• NCBI Official Full Name: exosome complex component RRP41
• NCBI Official Synonym Full Names: exosome component 4
• NCBI Official Symbol: EXOSC4
• NCBI Official Synonym Symbols: SKI6; p12A; RRP41; Ski6p; RRP41A; Rrp41p; hRrp41p
• NCBI Protein Information: exosome complex component RRP41
• UniProt Protein Name: Exosome complex component RRP41
• UniProt Gene Name: EXOSC4
• UniProt Synonym Gene Names: RRP41; SKI6

Uniprot Description

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs.