Rabbit SIPA1L1 Polyclonal Antibody | anti-SIPA1L1 antibody

SIPA1L1 Antibody

Cat. Num. AAA9401091

• Gene Names: SIPA1L1; E6TP1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity chromatography purified via peptide column
• Synonyms: SIPA1L1; Polyclonal Antibody; SIPA1L1 Antibody; Signal-induced proliferation associated-like protein 1; E6TP1; anti-SIPA1L1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 1804

• Applicable Applications for anti-SIPA1L1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 16 amino acid peptide from near the amino terminus of human SIPA1L1.
• Target Name: SIPA1L1
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of SIPA1L1 in rat brain tissue lysate with SIPA1L1 antibody at (A) 0.5 and (B) 1 ug/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of SIPA1L1 in human brain tissue with SIPA1L1 antibody at 5 ug/mL.)

Related Product Information for anti-SIPA1L1 antibody

Signal-induced proliferation associated-like protein 1 (SIPA1L1) is a member of the SIPA1 family of RapGAPs. SIPA1L1 was initially identified as a binding partner and degradation target of the E6 oncoprotein of high-risk papillomaviruses. Recently, it was discovered that Casein kinase I epsilon (CKIe), a Wnt-regulated kinase that regulates Wnt/b-catenin signaling, also can bind to the carboxy-terminus of SIPA1L1. CKIe phosphorylates SIPA1L1, thereby reducing its stability and alleviating its inhibition of Rap1, a protein required for Wnt8/CKIe-mediated gastrulation during embryogenesis, suggesting SIPA1L1 plays important roles in embryo development as well as control of cell proliferation.

Product Categories/Family for anti-SIPA1L1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 7662126
• NCBI GeneID: 26037
• NCBI Accession #: NP_056371
• NCBI GenBank Nucleotide #: NM_015556.2
• Molecular Weight: 197,408 Da
• NCBI Official Full Name: signal-induced proliferation-associated 1-like protein 1 isoform 1
• NCBI Official Synonym Full Names: signal-induced proliferation-associated 1 like 1
• NCBI Official Symbol: SIPA1L1
• NCBI Official Synonym Symbols: E6TP1
• NCBI Protein Information: signal-induced proliferation-associated 1-like protein 1
• UniProt Protein Name: Signal-induced proliferation-associated 1-like protein 1
• Protein Family: Signal-induced proliferation-associated 1-like protein
• UniProt Gene Name: SIPA1L1
• UniProt Synonym Gene Names: E6TP1; KIAA0440; SIPA1-like protein 1; E6-targeted protein 1
• UniProt Entry Name: SI1L1_HUMAN

Uniprot Description

SIPA1L1: Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F- actin. Contributes to the regulation of dendritic spine morphogenesis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs, Ras; GAPs

Chromosomal Location of Human Ortholog: 14q24.2

Cellular Component: postsynaptic membrane; cytoskeleton; cytoplasm; postsynaptic density; dendritic spine; cell junction

Molecular Function: ephrin receptor binding; GTPase activator activity

Biological Process: actin cytoskeleton reorganization; ephrin receptor signaling pathway; regulation of synaptic plasticity; regulation of axonogenesis