Rabbit anti-Human SIPA1L1 Polyclonal Antibody | anti-SIPA1L1 antibody

SIPA1L1, NT (Signal-induced Proliferation-associated 1-like Protein 1, SIPA1-like Protein 1, High-risk Human Papilloma Viruses E6 Oncoproteins Targeted Protein 1, E6-targeted Protein 1, E6TP1, KIAA0440)

Cat. Num. AAA648408

• Gene Names: SIPA1L1; E6TP1
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: SIPA1L1; Polyclonal Antibody; NT (Signal-induced Proliferation-associated 1-like Protein 1; SIPA1-like Protein 1; High-risk Human Papilloma Viruses E6 Oncoproteins Targeted Protein 1; E6-targeted Protein 1; E6TP1; KIAA0440); Anti -SIPA1L1; anti-SIPA1L1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human SIPA1L1. Species sequence homology: Mouse, rat.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.02% sodium azide.

• Applicable Applications for anti-SIPA1L1 antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA, Western Blot and Immunohistochemistry.; Dilution: Western Blot: 0.5-1ug/ml; Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml
• Immunogen: Synthetic peptide corresponding to human SIPA1L1 at N-terminal conjugated to KLH.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE))

Western Blot (WB)

(Western blot analysis of SIPA1L1 in rat brain tissue lysate with SIPA1L1 antibody at (A) 0.5 and (B) 1ug/ml.)

Related Product Information for anti-SIPA1L1 antibody

Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis.

Product Categories/Family for anti-SIPA1L1 antibody

Antibodies; Abs to Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 545746375
• NCBI GeneID: 26037
• NCBI Accession #: NP_001271175.1
• NCBI GenBank Nucleotide #: NM_001284246.1
• UniProt Accession #: O43166; O95321; Q9UDU4; Q9UNU4
• Molecular Weight: 200,029 Da
• NCBI Official Full Name: signal-induced proliferation-associated 1-like protein 1 isoform 3
• NCBI Official Synonym Full Names: signal-induced proliferation-associated 1 like 1
• NCBI Official Symbol: SIPA1L1
• NCBI Official Synonym Symbols: E6TP1
• NCBI Protein Information: signal-induced proliferation-associated 1-like protein 1; SIPA1-like protein 1; high-risk human papilloma viruses E6 oncoproteins targeted protein 1
• UniProt Protein Name: Signal-induced proliferation-associated 1-like protein 1
• Protein Family: Signal-induced proliferation-associated 1-like protein
• UniProt Gene Name: SIPA1L1
• UniProt Synonym Gene Names: E6TP1; KIAA0440; SIPA1-like protein 1
• UniProt Entry Name: SI1L1_HUMAN

Uniprot Description

Function: Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis

By similarity.

Subunit structure: Interacts with DLG4, PDLIM5, PDLIM7 and LZTS3. Interacts with the actin cytoskeleton

By similarity. Interacts (via PDZ domain) with EPHA4 (via PDZ motif); controls neuronal morphology through regulation of the RAP1 (RAP1A or RAP1B) and RAP2 (RAP2A, RAP2B or RAP2C) GTPases. Interacts with HPV E6. Ref.1 Ref.6

Subcellular location: Cytoplasm › cytoskeleton

By similarity. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density

By similarity. Cell junction › synapse › synaptosome

By similarity. Note: Associated with the actin cytoskeleton. Detected at synapses and dendritic spines of cultured hippocampal neurons

By similarity.

Tissue specificity: Widely expressed. Ref.1

Post-translational modification: Ubiquitinated and degraded by the SCF(BTRC) following phosphorylation by PLK2

By similarity.Phosphorylated at Ser-1349 by CDK5, creating a docking site for the POLO box domains of PLK2. Subsequently, PLK2 binds and phosphorylates SIPA1L1, leading to ubiquitination and degradation by the proteasome

By similarity.

Sequence similarities: Contains 1 PDZ (DHR) domain.Contains 1 Rap-GAP domain.

Sequence caution: The sequence BAA23712.2 differs from that shown. Reason: Erroneous initiation.