Mouse anti-Human Semaphorin 6A Polyclonal Antibody | anti-SEMA6A antibody

Semaphorin 6A (Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A-1) (SEMA6A, KIAA1368, SEMAQ)

Cat. Num. AAA619986

• Gene Names: SEMA6A; VIA; SEMA; HT018; SEMAQ; SEMA6A1; KIAA1368
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Serum; Serum
• Synonyms: Semaphorin 6A; Polyclonal Antibody; Semaphorin 6A (Semaphorin VIA; Sema VIA; Semaphorin-6A-1; SEMA6A-1) (SEMA6A; KIAA1368; SEMAQ); Anti -Semaphorin 6A (Semaphorin VIA; anti-SEMA6A antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human Semaphorin 6A.
• Purity/Purification: Serum; Serum
• Form/Format: Supplied as a liquid in 50% glycerol.

• Applicable Applications for anti-SEMA6A antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.
• Immunogen: Partial recombinant human Semaphorin 6A (21-120) with a GST tag.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(Western blot detection of GST tagged recombinant human Semaphorin 6A using MBS619986. Note the GST tag alone is 26 kDa.)

Related Product Information for anti-SEMA6A antibody

The transmembrane semaphorin Semaphorin 6A is expressed in developing neural tissue and is required for proper development of the thalamocortical neuron projection. Semaphorin 6A belongs to a subfamily characterized by an extracellular semaphorin domain, a transmembrane domain, and a long cytoplasmic tail. Members of this class can repel sympathetic and dorsal root ganglion axons in vitro, consistent with a traditional role as guidance signals. It was also suggested that Semaphorin 6A has a role in retrograde signaling.

Product Categories/Family for anti-SEMA6A antibody

Antibodies; Abs to Plexin; Semaphorin

NCBI and Uniprot Product Information

• NCBI GI #: 11991660
• NCBI GeneID: 57556
• NCBI Accession #: NP_065847.1
• NCBI GenBank Nucleotide #: NM_020796.3
• UniProt Accession #: Q9H2E6; Q9P2H9; Q8NC49; Q96JU9; Q96SM8; Q96SW4; Q96SY4; Q96T04; Q9HBL2
• Molecular Weight: 114,395 Da
• NCBI Official Full Name: semaphorin-6A
• NCBI Official Synonym Full Names: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
• NCBI Official Symbol: SEMA6A
• NCBI Official Synonym Symbols: VIA; SEMA; HT018; SEMAQ; SEMA6A1; KIAA1368
• NCBI Protein Information: semaphorin-6A; SEMA6A-1; sema VIa; semaphorin VIA; semaphorin 6A-1; semaphorin-6A-1; OTTHUMP00000223008; OTTHUMP00000223009; OTTHUMP00000223010
• UniProt Protein Name: Semaphorin-6A
• Protein Family: Semaphorin
• UniProt Gene Name: SEMA6A
• UniProt Synonym Gene Names: KIAA1368; SEMAQ
• UniProt Entry Name: SEM6A_HUMAN

NCBI Description

The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).[supplied by OMIM]

Uniprot Description

SEMA6A: a single-pass type I membrane protein of the semaphorin family that can act as repulsive axon guidance cues. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation. Active as a homodimer or oligomer. Interacts with EVL. Two isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q23.1

Cellular Component: axon; integral to membrane; plasma membrane

Molecular Function: protein binding; receptor activity

Biological Process: axon guidance; nervous system development; organ morphogenesis; cell surface receptor linked signal transduction; apoptosis; cytoskeleton organization and biogenesis