Western Blot (WB)
(PCSK5 Antibody (N-term) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the PCSK5 antibody detected the PCSK5 protein (arrow).)
Rabbit anti-Human PCSK5 Polyclonal Antibody | anti-PCSK5 antibody
PCSK5 Antibody (N-term)
Western Blot (WB)
(PCSK5 Antibody (N-term) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the PCSK5 antibody detected the PCSK5 protein (arrow).)
Western Blot (WB)
(PCSK5 Antibody (N-term) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the PCSK5 antibody detected the PCSK5 protein (arrow).)
subtilisin-like proprotein convertase family. The members of this
family are proprotein convertases that process latent precursor
proteins into their biologically active products. This encoded
protein mediates posttranslational endoproteolytic processing for
several integrin alpha subunits. It is thought to process prorenin,
pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein
gp160. Multiple transcript variants encoding different isoforms
have been found for this gene.
Heng, S., et al. Endocrinology 151(8):3909-3917(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Iatan, I., et al. Circ Cardiovasc Genet 2(5):467-475(2009)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B). [provided by RefSeq, May 2014]
Uniprot Description
PCSK5: Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2 and CALD1. Belongs to the peptidase S8 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Protease; EC 3.4.21.-; Membrane protein, integral
Chromosomal Location of Human Ortholog: 9q21.3
Cellular Component: Golgi apparatus; extracellular space; Golgi lumen; integral to membrane; secretory granule
Molecular Function: peptidase activity; serine-type endopeptidase activity; peptide binding
Biological Process: signal peptide processing; nerve growth factor receptor signaling pathway; heart development; respiratory tube development; cytokine biosynthetic process; embryonic skeletal development; peptide hormone processing; viral infectious cycle; proteolysis; limb morphogenesis; peptide biosynthetic process; anterior/posterior pattern formation; nerve growth factor processing; renin secretion into blood stream; cell-cell signaling; protein processing; kidney development; embryonic gut development; embryo implantation
Research Articles on PCSK5
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Product Notes
The PCSK5 pcsk5 (Catalog #AAA9200746) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 95-124. The PCSK5 Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PCSK5 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the PCSK5 pcsk5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PCSK5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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