Rabbit SELENOK Polyclonal Antibody | anti-SELENOK antibody

SELENOK Antibody

Cat. Num. AAA9630576

• Gene Names: SELK; SelK; HSPC030; HSPC297
• Reactivity: Human, Mouse, Rat
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: SELENOK; Polyclonal Antibody; SELENOK Antibody; HSPC030; HSPC297; Selenoprotein K; SelK; SELK_HUMAN; anti-SELENOK antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: SELENOK Antibody detects endogenous levels of SELENOK.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-SELENOK antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human SELENOK.
• Conjugation: Unconjugated
• Similarity: Belongs to the selenoprotein K family.
• Post Translational Modifications: Cleaved by CAPN2/m-calpain in resting macrophages but not in activated macrophages. Macrophage activation up-regulates expression of the calpain inhibitor CAST/calpastatin, resulting in inhibition of CAPN2 activity (By similarity).
• Subunit Structure: Interacts with DERL1, DERL2, DERL3 and SELENOS. The SELENOK-SELENOS complex interacts with VCP. Interacts with ZDHHC6.
• Tissue Specificity: Highly expressed in heart.
• Function: Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins. Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Plays a role in protection of cells from ER stress-induced apoptosis. Protects cells from oxidative stress when overexpressed in cardiomyocytes.
• Note: Probably mainly localized in the ER.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-SELENOK antibody

Endoplasmic reticulum membrane; Single-pass membrane protein; Cell membrane; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 25014099
• NCBI GeneID: 58515
• NCBI Accession #: NP_067060
• NCBI GenBank Nucleotide #: NM_021237.3
• UniProt Accession #: Q9Y6D0; Q8IZQ3; Q9P085
• Molecular Weight: 10 kDa
• NCBI Official Full Name: selenoprotein K
• NCBI Official Symbol: SELK
• NCBI Official Synonym Symbols: SelK; HSPC030; HSPC297
• NCBI Protein Information: selenoprotein K
• UniProt Protein Name: Selenoprotein K
• UniProt Gene Name: SELK
• UniProt Synonym Gene Names: SelK
• UniProt Entry Name: SELK_HUMAN

NCBI Description

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is localized to the endoplasmic reticulum and is highly expressed in the heart, where it may function as an antioxidant. [provided by RefSeq, Jul 2008]

Uniprot Description

SELK: a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is localized to the endoplasmic reticulum and is highly expressed in the heart, where it may function as an antioxidant. [provided by RefSeq, Jul 2008]

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane; plasma membrane

Molecular Function: identical protein binding

Biological Process: calcium ion transport; response to oxidative stress