Rabbit SCARB1 Polyclonal Antibody | anti-SCARB1 antibody

SCARB1 Antibody

Cat. Num. AAA9402837

• Gene Names: SCARB1; CLA1; SRB1; CLA-1; SR-BI; CD36L1; HDLQTL6
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity chromatography purified via peptide column
• Synonyms: SCARB1; Polyclonal Antibody; SCARB1 Antibody; Scavenger receptor class B member 1; SRB1; SR-BI; CD36 antigen-like 1; CD36 and LIMPII analogous 1; CLA-1; CLA1; anti-SCARB1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 506

• Applicable Applications for anti-SCARB1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 15 amino acid peptide near the amino terminus of human SCARB1.
• Target Name: SCARB1
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of SCARB1 in human spleen tissue lysate with SCARB1 antibody at (A) 1 and (B) 2 ug/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of SCARB1 in human spleen tissue with SCARB1 antibody at 2.5 ug/mL.)

Related Product Information for anti-SCARB1 antibody

Scavenger receptor class B member 1 (SCARB1), also known as SR-BI, is part of the scavenger receptor superfamily, which is composed of many members with diverse structures, expression patterns, and functions. SCARB1 is a multi-ligand cell-surface receptor that mediates the selective uptake of lipid from HDL cholesterol into cells and is expressed in steroidogenic tissues in adult animals. Other ligands of SCARB1 include native, acetylated, or oxidized LDL and anionic phospholipids. SCARB1-deficient mice have elevated HDL levels and increased susceptibility to atherosclerosis on fat feeding, indicating its importance in the regulation of cholesterol homeostasis. Along with CLDN1, LDL-R, and the tetraspanin superfamily member CD81, SCARB1 has been reported to be an entry factor for the Hepatitis C virus. At least two isoforms of SCARB1 are known to exist.

Product Categories/Family for anti-SCARB1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 132566680
• NCBI GeneID: 949
• NCBI Accession #: NP_001076428.1
• NCBI GenBank Nucleotide #: NM_001082959.1
• UniProt Accession #: Q8WTV0; Q14016; Q52LZ5; Q6KFX4; F8W8N0
• Molecular Weight: 56,170 Da
• NCBI Official Full Name: scavenger receptor class B member 1 isoform 2
• NCBI Official Synonym Full Names: scavenger receptor class B, member 1
• NCBI Official Symbol: SCARB1
• NCBI Official Synonym Symbols: CLA1; SRB1; CLA-1; SR-BI; CD36L1; HDLQTL6
• NCBI Protein Information: scavenger receptor class B member 1
• UniProt Protein Name: Scavenger receptor class B member 1
• Protein Family: Scavenger receptor
• UniProt Gene Name: SCARB1
• UniProt Synonym Gene Names: CD36L1; CLA1; SRB1; CLA-1
• UniProt Entry Name: SCRB1_HUMAN

NCBI Description

The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]

Uniprot Description

Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (PubMed:12016218, PubMed:12519372, PubMed:21226579). Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as high density lipoproteins (HDL) and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Necessary for selective HDL-cholesterol uptake (PubMed:26965621). Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (PubMed:12016218).