Western Blot (WB)
(Western blot analysis of rat apotransferrin protein probed with transferrin pAb.)
Rabbit Transferrin Polyclonal Antibody | anti-TF antibody
Transferrin polyclonal antibody
Detects a band of ~76kDa by Western blot.
Avoid freeze/thaw cycles.
Western Blot (WB)
(Western blot analysis of rat apotransferrin protein probed with transferrin pAb.)
Western Blot (WB)
(Western blot analysis of rat apotransferrin protein probed with transferrin pAb.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]
Uniprot Description
TF: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. Defects in TF are the cause of atransferrinemia (ATRAF). Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia. Belongs to the transferrin family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 3q22.1
Cellular Component: apical plasma membrane; basal plasma membrane; cell surface; coated pit; cytoplasmic vesicle; early endosome; endocytic vesicle; endosome membrane; extracellular region; extracellular space; extrinsic to external side of plasma membrane; late endosome; perinuclear region of cytoplasm; recycling endosome; vesicle
Molecular Function: ferrous iron binding; protein binding
Biological Process: cellular iron ion homeostasis; iron ion homeostasis; platelet degranulation; positive regulation of receptor-mediated endocytosis; regulation of protein stability; retinal homeostasis; transferrin transport
Disease: Atransferrinemia
Research Articles on TF
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Product Notes
The TF tf (Catalog #AAA565751) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Transferrin polyclonal antibody reacts with Human, Mouse, Rat, Dog, Guinea pig and may cross-react with other species as described in the data sheet. AAA Biotech's Transferrin can be used in a range of immunoassay formats including, but not limited to, Immunoprecipitation (IP), Western Blot (WB). Western Blot (1:2'000, ECL). Detects a band of ~76kDa by Western blot. Researchers should empirically determine the suitability of the TF tf for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Transferrin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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