Western Blot (WB)
(mouse brain tissue were subjected to SDS PAGE followed by western blot with MBS7603744 (RSPO2 antibody) at dilution of 1:1000)
Rabbit RSPO2 Polyclonal Antibody | anti-RSPO2 antibody
RSPO2 Rabbit Polyclonal
Immunogen Affinity Purified
Immunogen Affinity Purified
Western Blot (WB)
(mouse brain tissue were subjected to SDS PAGE followed by western blot with MBS7603744 (RSPO2 antibody) at dilution of 1:1000)
Western Blot (WB)
(mouse brain tissue were subjected to SDS PAGE followed by western blot with MBS7603744 (RSPO2 antibody) at dilution of 1:1000)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the R-spondin family of proteins. These proteins are secreted ligands of leucine-rich repeat containing G protein-coupled receptors that enhance Wnt signaling through the inhibition of ubiquitin E3 ligases. A chromosomal translocation including this locus that results in the formation of a gene fusion has been identified in multiple human cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Description
R-spondin-2: Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors. Belongs to the R-spondin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Cell development/differentiation; Secreted
Chromosomal Location of Human Ortholog: 8q23.1
Cellular Component: cell surface; extracellular region
Molecular Function: heparin binding; protein binding; receptor binding
Biological Process: bone mineralization; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; negative regulation of odontogenesis of dentine-containing teeth; osteoblast differentiation; positive regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway
Research Articles on RSPO2
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Product Notes
The RSPO2 rspo2 (Catalog #AAA7603744) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RSPO2 Rabbit Polyclonal reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's RSPO2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the RSPO2 rspo2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RSPO2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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