Rabbit anti-Human, Mouse RRAGC Polyclonal Antibody | anti-RRAGC antibody

RRAGC Antibody

Cat. Num. AAA9410858

• Gene Names: RRAGC; GTR2; RAGC; TIB929
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Antigen affinity purification.
• Synonyms: RRAGC; Polyclonal Antibody; RRAGC Antibody; GTR2; RAGC; TIB929; anti-RRAGC antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total RRAGC protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Concentration: 1.5 mg/ml (varies by lot)
• Sequence Length: 365

• Applicable Applications for anti-RRAGC antibody: Western Blot (WB)
• Application Notes: Western blotting: 1:500-1:2000
• Immunogen Type: Protein
• Immunogen Description: Full length fusion protein
• Target Name: RRAGC
• Preparation and Storage: Store at -20 degree C

Testing Data

(Gel: 8%SDS-PAGE Lysates (from left to right): K562 and NIH/3T3 cellAmount of lysate: 40ug per lane Primary antibody: 1/400 dilution Secondary antibody dilution: 1/8000Exposure time: 5 seconds)

Related Product Information for anti-RRAGC antibody

This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants.

Product Categories/Family for anti-RRAGC antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 427918102
• NCBI GeneID: 64121
• NCBI Accession #: NP_001258780.1
• NCBI GenBank Nucleotide #: NM_001271851.1
• UniProt Accession #: Q9HB90; Q9H202; Q9H8Q8
• Molecular Weight: 44,224 Da
• NCBI Official Full Name: ras-related GTP-binding protein C isoform 2
• NCBI Official Synonym Full Names: Ras-related GTP binding C
• NCBI Official Symbol: RRAGC
• NCBI Official Synonym Symbols: GTR2; RAGC; TIB929
• NCBI Protein Information: ras-related GTP-binding protein C
• UniProt Protein Name: Ras-related GTP-binding protein C
• Protein Family: Ras-related GTP-binding protein
• UniProt Gene Name: RRAGC
• UniProt Synonym Gene Names: Rag C; RagC
• UniProt Entry Name: RRAGC_HUMAN

NCBI Description

This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Uniprot Description

RRAGC: Has guanine nucleotide-binding activity but weak intrinsic GTPase activity. Probably required for the amino acid- induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Forms a heterodimer with RRAGA in a sequence-independent manner. Binds GTP. Interacts with NOL8 and RRAGB. Belongs to the GTR/RAG GTP-binding protein family.

Chromosomal Location of Human Ortholog: 1p34

Cellular Component: nucleoplasm; intracellular membrane-bound organelle; lysosome; cytoplasm; nucleus

Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; protein heterodimerization activity; magnesium ion binding

Biological Process: transcription, DNA-dependent; apoptosis; RNA splicing; small GTPase mediated signal transduction; regulation of autophagy; cellular response to starvation; cell growth; positive regulation of TOR signaling pathway