Rabbit anti-Human RBMS1 Polyclonal Antibody | anti-RBMS1 antibody

RBMS1, ID (RBMS1, C2orf12, MSSP, MSSP1, SCR2, RNA-binding motif, single-stranded-interacting protein 1, Single-stranded DNA-binding protein MSSP-1, Suppressor of CDC2 with RNA-binding motif 2) (APC)

Cat. Num. AAA6340851

• Gene Names: RBMS1; YC1; MSSP; SCR2; HCC-4; MSSP-1; MSSP-2; MSSP-3; C2orf12
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: RBMS1; Polyclonal Antibody; ID (RBMS1; C2orf12; MSSP; MSSP1; SCR2; RNA-binding motif; single-stranded-interacting protein 1; Single-stranded DNA-binding protein MSSP-1; Suppressor of CDC2 with RNA-binding motif 2) (APC); Suppressor of CDC2 with RNA-binding motif 2; anti-RBMS1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-RBMS1 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: RBMS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 223-252 amino acids from the Central region of human RBMS1.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(RBMS1 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the RBMS1 antibody detected the RBMS1 protein (arrow).)

Related Product Information for anti-RBMS1 antibody

This gene encodes a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. These proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. Several transcript variants, resulting from alternative splicing and encoding different isoforms, have been described. A pseudogene for this locus is found on chromosome 12.

Product Categories/Family for anti-RBMS1 antibody

Antibodies; Cell Division Cycle (CDC)

References

Qi, L., et al. Hum. Mol. Genet. 19(13):2706-2715(2010). Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Landers, J.E., et al. Proc. Natl. Acad. Sci. U.S.A. 106(22):9004-9009(2009). Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007). Lamesch, P., et al. Genomics 89(3):307-315(2007).

NCBI and Uniprot Product Information

• NCBI GI #: 4506447
• NCBI GeneID: 5937
• NCBI Accession #: NP_002888.1; NP_058520.1
• NCBI GenBank Nucleotide #: NM_002897.4
• UniProt Accession #: P29558; Q14869; Q15433; Q53P46; Q53QX8; Q53RG6; Q8WV20
• Molecular Weight: 44,505 Da
• NCBI Official Full Name: RNA-binding motif, single-stranded-interacting protein 1 isoform c
• NCBI Official Synonym Full Names: RNA binding motif, single stranded interacting protein 1
• NCBI Official Symbol: RBMS1
• NCBI Official Synonym Symbols: YC1; MSSP; SCR2; HCC-4; MSSP-1; MSSP-2; MSSP-3; C2orf12
• NCBI Protein Information: RNA-binding motif, single-stranded-interacting protein 1; cervical cancer oncogene 4; c-myc gene single strand binding protein 2; single-stranded DNA-binding protein MSSP-1; suppressor of CDC2 with RNA-binding motif 2; suppressor of cdc 2 (cdc13) with RNA
• UniProt Protein Name: RNA-binding motif, single-stranded-interacting protein 1
• Protein Family: RNA-binding motif, single-stranded-interacting protein
• UniProt Gene Name: RBMS1
• UniProt Synonym Gene Names: C2orf12; MSSP; MSSP1; SCR2
• UniProt Entry Name: RBMS1_HUMAN

Uniprot Description

RBMS1: Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA replication; RNA-binding

Chromosomal Location of Human Ortholog: 2q24.2

Cellular Component: nucleus

Molecular Function: protein binding; RNA binding; double-stranded DNA binding; nucleotide binding; single-stranded DNA binding

Biological Process: RNA processing; DNA replication