Rabbit anti-Human, Mouse RBM15B Polyclonal Antibody | anti-RBM15B antibody

RBM15B Polyclonal Antibody

Cat. Num. AAA2556014

• Gene Names: RBM15B; OTT3; HsOTT3; HUMAGCGB
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Affinity Purification
• Synonyms: RBM15B; Polyclonal Antibody; RBM15B Polyclonal Antibody; RNA Binding Motif Protein 15B; HuOTT3; OTT3; Putative RNA-Binding Protein 15B; Chromosome 3p21.1 Gene Sequence; RNA-Binding Motif Protein 15B; One Twenty Two Protein 3; One-Twenty Two Protein 3; HUMAGCGB; anti-RBM15B antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 563

• Applicable Applications for anti-RBM15B antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Recombinant protein of human RBM15B
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using RBM15B Antibody.)

NCBI and Uniprot Product Information

• NCBI GI #: 54607124
• NCBI GeneID: 29890
• NCBI Accession #: NP_037418.3
• NCBI GenBank Nucleotide #: NM_013286.5
• UniProt Accession #: Q8NDT2; Q6QE19; Q9BV96; A4QPG7
• Molecular Weight: Calculated: 63kDa; 97kDa; Observed: 97kDa
• NCBI Official Full Name: putative RNA-binding protein 15B
• NCBI Official Synonym Full Names: RNA binding motif protein 15B
• NCBI Official Symbol: RBM15B
• NCBI Official Synonym Symbols: OTT3; HsOTT3; HUMAGCGB
• NCBI Protein Information: putative RNA-binding protein 15B
• UniProt Protein Name: Putative RNA-binding protein 15B
• Protein Family: Putative RNA-binding protein
• UniProt Gene Name: RBM15B
• UniProt Synonym Gene Names: HsOTT31 PublicationManual assertion based on opinion iniRef.10; HuOTT31 PublicationManual assertion based on opinion iniRef.5

NCBI Description

Members of the SPEN (Split-end) family of proteins, including RBM15B, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]

Uniprot Description

RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:16129689, PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:27602518). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation (PubMed:16129689). Inhibits pre-mRNA splicing (PubMed:21044963). Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 (PubMed:19586903).