Rabbit anti-Mouse LPAR6 Polyclonal Antibody | anti-LPAR6 antibody

LPAR6, ID (LPAR6, P2RY5, Lysophosphatidic acid receptor 6, Oleoyl-L-alpha-lysophosphatidic acid receptor, P2Y purinoceptor 5, Purinergic receptor 5, RB intron encoded G-protein coupled receptor) (PE)

Cat. Num. AAA6316800

• Gene Names: LPAR6; LAH3; P2Y5; ARWH1; P2RY5
• Reactivity: Mouse
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: LPAR6; Polyclonal Antibody; ID (LPAR6; P2RY5; Lysophosphatidic acid receptor 6; Oleoyl-L-alpha-lysophosphatidic acid receptor; P2Y purinoceptor 5; Purinergic receptor 5; RB intron encoded G-protein coupled receptor) (PE); RB intron encoded G-protein coupled receptor; anti-LPAR6 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes mouse LPAR6. Predicted to cross-react with rat.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-LPAR6 antibody: Immunohistochemistry (IHC), FLISA, Western Blot (WB)
• Application Notes: IHC: 1:10-50; FLISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide corresponding to a portion of amino acids within aa106-134 in the central region of human LPAR6, UniProt Accession #P43657.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western blot analysis of LPAR6 in mouse heart tissue lysate (35ug/lane) using antibodyMBS644855.)

Immunohistochemistry (IHC)

(IHC analysis of LPAR6 in formalin-fixed, paraffin-embedded human breast carcinoma using antibodyMBS644855. Peroxidase-conjugated secondary antibody and DAB staining were used for visualization. )

Related Product Information for anti-LPAR6 antibody

The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants.

Product Categories/Family for anti-LPAR6 antibody

Antibodies; G Protein Receptors

References

Pasternack, S.M., et al. Arch. Dermatol. Res. 301(8):621-624(2009). Yanagida, K., et al. J. Biol. Chem. 284(26):17731-17741(2009). Tariq, M., et al. Br. J. Dermatol. 160(5):1006-1010(2009). Shimomura, Y., et al. J. Invest. Dermatol. 129(3):622-628(2009). Dereure, O. Ann Dermatol Venereol 135(11):794-795(2008).

NCBI and Uniprot Product Information

• NCBI GI #: 241982708
• NCBI GeneID: 10161
• NCBI Accession #: NP_001155970.1; NP_005758.2
• NCBI GenBank Nucleotide #: NM_001162498.1
• UniProt Accession #: P43657; O15133; Q3KPF5; Q53FA0; Q5VW44; Q7Z3S0; Q7Z3S6; A4FTW9; B3KVF2
• Molecular Weight: 39,392 Da
• NCBI Official Full Name: lysophosphatidic acid receptor 6
• NCBI Official Synonym Full Names: lysophosphatidic acid receptor 6
• NCBI Official Symbol: LPAR6
• NCBI Official Synonym Symbols: LAH3; P2Y5; ARWH1; P2RY5
• NCBI Protein Information: lysophosphatidic acid receptor 6; LPA-6; LPA receptor 6; P2Y purinoceptor 5; purinergic receptor 5; G-protein coupled purinergic receptor P2Y5; RB intron encoded G-protein coupled receptor; oleoyl-L-alpha-lysophosphatidic acid receptor; purinergic recepto
• UniProt Protein Name: Lysophosphatidic acid receptor 6
• Protein Family: Lysophosphatidic acid receptor
• UniProt Gene Name: LPAR6
• UniProt Synonym Gene Names: P2RY5; LPA receptor 6; LPA-6; P2Y5
• UniProt Entry Name: LPAR6_HUMAN

NCBI Description

The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]

Uniprot Description

P2RY5: Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture. Defects in LPAR6 are the cause of woolly hair autosomal recessive type 1 with or without hypotrichosis (ARWH1). A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. Defects in LPAR6 are the cause of hypotrichosis type 8 (HYPT8). A condition characterized by the presence of less than the normal amount of hair. Affected individuals show progressive hair loss, thinning of scalp hair since early childhood, sparse body hair, and sparse eyebrows and eyelashes in some cases. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 13q14

Cellular Component: plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway

Disease: Hypotrichosis 8