Western Blot (WB)
(EIF2B4 Antibody (Center K161) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the EIF2B4 antibody detected the EIF2B4 protein (arrow).)
Rabbit EIF2B4 Polyclonal Antibody | anti-EIF2B4 antibody
EIF2B4 Antibody (Center K161)
Western Blot (WB)
(EIF2B4 Antibody (Center K161) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the EIF2B4 antibody detected the EIF2B4 protein (arrow).)
Western Blot (WB)
(EIF2B4 Antibody (Center K161) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the EIF2B4 antibody detected the EIF2B4 protein (arrow).)
Western Blot (WB)
(EIF2B4 Antibody (Center K161) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the EIF2B4 antibody detected the EIF2B4 protein (arrow).)
Western Blot (WB)
(EIF2B4 Antibody (Center K161) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the EIF2B4 antibody detected the EIF2B4 protein (arrow).)
Immunohistochemistry (IHC)
(EIF2B4 Antibody (Center K161) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of EIF2B4 Antibody (Center K161) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(EIF2B4 Antibody (Center K161) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of EIF2B4 Antibody (Center K161) for immunohistochemistry. Clinical relevance has not been evaluated.)
necessary for protein synthesis, is a GTP exchange factor composed
of five different subunits. The protein encoded by this gene is the
fourth, or delta, subunit. Defects in this gene are a cause of
leukoencephalopathy with vanishing white matter (VWM) and
ovarioleukodystrophy. Multiple transcript variants encoding
different isoforms have been found for this gene. [provided by
RefSeq].
Wu, Y., et al. J. Hum. Genet. 54(2):74-77(2009)
Horzinski, L., et al. PLoS ONE 4 (12), E8318 (2009) :
Pronk, J., et al. Mult. Scler. 14(8):1123-1126(2008)
Wong, S.S., et al. J. Child Neurol. 23(6):710-714(2008)
NCBI and Uniprot Product Information
NCBI Description
Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
eIF2B-delta: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Defects in EIF2B4 are a cause of leukodystrophy with vanishing white matter (VWM). VWM is a leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or adulthood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy. Belongs to the eIF-2B alpha/beta/delta subunits family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Translation initiation; Translation
Chromosomal Location of Human Ortholog: 2p23.3
Cellular Component: eukaryotic translation initiation factor 2B complex; cytoplasm; cytosol
Molecular Function: protein binding; translation initiation factor binding; translation initiation factor activity; guanyl-nucleotide exchange factor activity; S-methyl-5-thioribose-1-phosphate isomerase activity
Biological Process: myelination; response to peptide hormone stimulus; negative regulation of translational initiation; translation; cellular response to stimulus; regulation of translation; cellular protein metabolic process; ovarian follicle development; methionine salvage; response to heat; translational initiation; response to glucose stimulus; negative regulation of translation initiation in response to stress; gene expression; oligodendrocyte development; regulation of translational initiation; positive regulation of GTPase activity
Disease: Leukoencephalopathy With Vanishing White Matter
Research Articles on EIF2B4
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Product Notes
The EIF2B4 eif2b4 (Catalog #AAA9201859) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 146-175. The EIF2B4 Antibody (Center K161) reacts with Human, mouse (Predicted Reactivity: Bovine) and may cross-react with other species as described in the data sheet. AAA Biotech's EIF2B4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the EIF2B4 eif2b4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "EIF2B4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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