Rabbit anti-Human, Mouse RBM15 Polyclonal Antibody | anti-RBM15 antibody

Anti-RBM15 Antibody

Cat. Num. AAA8307893

• Gene Names: RBM15; OTT; OTT1; SPEN
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Purified by Immunogen Affinity Chromatography
• Synonyms: RBM15; Polyclonal Antibody; Anti-RBM15 Antibody; OTT; OTT1; Putative RNA-binding protein 15; One-twenty two protein 1; RNA-binding motif protein 15; anti-RBM15 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: Recognizes endogenous levels of RBM15 protein.
• Purity/Purification: Purified by Immunogen Affinity Chromatography
• Form/Format: Liquid in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3, 30% Glycerol, and 0.01% Sodium Azide.

• Applicable Applications for anti-RBM15 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Recombinant fusion protein of human RBM15. The exact sequence is proprietary.
• Preparation and Storage: Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of RBM15 expression in HepG2 (A), Jurkat (B), mouse spleen (C) whole cell lysates.)

Related Product Information for anti-RBM15 antibody

Rabbit polyclonal antibody to RBM15

NCBI and Uniprot Product Information

• NCBI GI #: 32363506
• NCBI GeneID: 64783
• UniProt Accession #: Q96T37; Q3ZB86; Q4V760; Q5D058; Q5T613; Q86VW9; Q96PE4; Q96SC5; Q96SC6; Q96SC9; Q96SD0; A1A693
• Molecular Weight: 977
• NCBI Official Full Name: Putative RNA-binding protein 15
• NCBI Official Synonym Full Names: RNA binding motif protein 15
• NCBI Official Symbol: RBM15
• NCBI Official Synonym Symbols: OTT; OTT1; SPEN
• NCBI Protein Information: putative RNA-binding protein 15; one twenty-two; one twenty two protein; one-twenty two protein 1; RNA-binding motif protein 15
• UniProt Protein Name: Putative RNA-binding protein 15
• Protein Family: Putative RNA-binding protein
• UniProt Gene Name: RBM15
• UniProt Synonym Gene Names: OTT; OTT1
• UniProt Entry Name: RBM15_HUMAN

NCBI Description

Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]

Uniprot Description

RBM15: May be implicated in HOX gene regulation. A chromosomal aberration involving RBM15 may be a cause of acute megakaryoblastic leukemia. Translocation t(1;22)(p13;q13) with MKL1. Although both reciprocal fusion transcripts are detected in acute megakaryoblastic leukemia (AMKL, FAB-M7), the RBM15-MKL1 chimeric protein has all the putative functional domains encoded by each gene and is the candidate oncogene. Belongs to the RRM Spen family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Spliceosome; Oncoprotein; RNA-binding

Chromosomal Location of Human Ortholog: 1p13

Cellular Component: nucleoplasm; nuclear membrane

Molecular Function: protein binding; nucleotide binding

Biological Process: spleen development; patterning of blood vessels; negative regulation of myeloid cell differentiation; viral reproduction; negative regulation of transcription, DNA-dependent; activation of Notch receptor target transcription factor