Rabbit PPP2R1B Polyclonal Antibody | anti-PPP2R1B antibody

PPP2R1B Rabbit Polyclonal

Cat. Num. AAA7602948

• Gene Names: PPP2R1B; PR65B; PP2A-Abeta
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: PPP2R1B; Polyclonal Antibody; PPP2R1B Rabbit Polyclonal; anti-PPP2R1B antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 601

• Applicable Applications for anti-PPP2R1B antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded mouse lung using MBS7602948 (PPP2R1B antibody) at dilution of 1:100)

Western Blot (WB)

(SW480 cells were subjected to SDS PAGE followed by western blot with MBS7602948 (PPP2R1B antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 3820592
• NCBI GeneID: 5519
• Molecular Weight: 52,214 Da
• NCBI Official Full Name: protein phosphatase 2 subunit A isoform beta
• NCBI Official Synonym Full Names: protein phosphatase 2 scaffold subunit Abeta
• NCBI Official Symbol: PPP2R1B
• NCBI Official Synonym Symbols: PR65B; PP2A-Abeta
• NCBI Protein Information: serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
• UniProt Protein Name: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
• UniProt Gene Name: PPP2R1B
• UniProt Entry Name: 2AAB_HUMAN

NCBI Description

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

Uniprot Description

PPP2R1B: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Belongs to the phosphatase 2A regulatory subunit A family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein phosphatase, regulatory subunit

Chromosomal Location of Human Ortholog: 11q23.2

Cellular Component: lipid raft

Molecular Function: protein binding; protein phosphatase type 2A regulator activity

Biological Process: protein complex assembly; regulation of protein phosphatase type 2A activity

Disease: Lung Cancer