Goat RANBP7 Polyclonal Antibody | anti-RANBP9 antibody

RANBP7 (Importin-7, Imp7, Ran-binding Protein 7, RanBP7, IPO7)

Cat. Num. AAA643167

• Gene Names: RANBP9; BPM-L; BPM90; RANBPM; RanBP7
• Reactivity: Bovine, Canine, Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: RANBP7; Polyclonal Antibody; RANBP7 (Importin-7; Imp7; Ran-binding Protein 7; RanBP7; IPO7); Anti -RANBP7 (Importin-7; anti-RANBP9 antibody

• Host: Goat
• Reactivity: Bovine, Canine, Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: Recognizes human IPO7. Species sequence homology: Bovine, canine, mouse and rat.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

• Applicable Applications for anti-RANBP9 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA: 1:32,000; Western Blot: 0.1-1ug/ml, observed in human brain lysates on ~120kD bands
• Immunogen: Synthetic peptide corresponding to C-SSFNFGGPAPGMN, from human IPO7, at C-terminal (NP_006382.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot of Daudi lysate (35ug/lane RIPA buffer) usung MBS643167 (0.1ug/ml). Primary incubated for 1 hour. Detected using chemiluminescence.)

Related Product Information for anti-RANBP9 antibody

The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran binding site of importin beta. Similar to importin beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta like transport receptors, namely importin beta itself, transportin, RanBP5 and importin 7, directly bind and import ribosomal proteins.

Product Categories/Family for anti-RANBP9 antibody

Antibodies; Abs to Nuclear Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 39812378
• NCBI GeneID: 10048
• NCBI Accession #: NP_005484.2
• NCBI GenBank Nucleotide #: NM_005493.2
• UniProt Accession #: Q96S59; O94764; Q6P3T7; Q7LBR2; Q7Z7F9; A0PJA2
• Molecular Weight: 77,847 Da
• NCBI Official Full Name: ran-binding protein 9
• NCBI Official Synonym Full Names: RAN binding protein 9
• NCBI Official Symbol: RANBP9
• NCBI Official Synonym Symbols: BPM-L; BPM90; RANBPM; RanBP7
• NCBI Protein Information: ran-binding protein 9; ran-binding protein M; novel centrosomal protein RanBPM; ran binding protein, centrosomal; Ran Binding Protein in the Microtubule organizing center
• UniProt Protein Name: Ran-binding protein 9
• Protein Family: Ran-binding protein
• UniProt Gene Name: RANBP9
• UniProt Synonym Gene Names: RANBPM; RanBP9; RanBPM
• UniProt Entry Name: RANB9_HUMAN

NCBI Description

This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this gene has also been shown to interact with several other proteins, including met proto-oncogene, homeodomain interacting protein kinase 2, androgen receptor, and cyclin-dependent kinase 11. [provided by RefSeq, Jul 2008]

Uniprot Description

RANBP9: May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. Belongs to the RANBP9/10 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; GAPs; GAPs, Ras; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 6p23

Cellular Component: microtubule associated complex; cytosol; nucleus

Molecular Function: protein binding; enzyme binding; Ran GTPase binding

Biological Process: axon guidance; protein complex assembly; microtubule nucleation