Western Blot (WB)
(RALA Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the RALA antibody detected the RALA protein (arrow).)
Rabbit RALA Polyclonal Antibody | anti-RALA antibody
RALA Antibody (C-term)
Western Blot (WB)
(RALA Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the RALA antibody detected the RALA protein (arrow).)
Western Blot (WB)
(RALA Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the RALA antibody detected the RALA protein (arrow).)
superfamily, Ras family of proteins. GTP-binding proteins mediate
the transmembrane signaling initiated by the occupancy of certain
cell surface receptors. This gene encodes a low molecular mass
ras-like GTP-binding protein that shares about 50% similarity with
other ras proteins.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Godin, C.M., et al. Mol. Pharmacol. 77(3):388-395(2010)
Lim, K.H., et al. Mol. Cell. Biol. 30(2):508-523(2010)
Wang, K., et al. Int J Immunopathol Pharmacol 22(3):735-743(2009)
NCBI and Uniprot Product Information
NCBI Description
The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins. [provided by RefSeq, Jul 2008]
Uniprot Description
RALA: Multifuntional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin- dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with ADRBK1 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells. Interacts with RALBP1 via its effector domain. Interacts with EXOC8 and EXOC2. EXOC2 and EXOC8 have overlapping binding sites and compete for RALA binding. Interacts with Clostridium exoenzyme C3. Interacts with RALGPS1. Interacts with LPAR1 and LPAR2. Interacts with ADRBK1 in response to LPAR1 activation. RALA and ADRBK1 mutually inhibit each other's binding to LPAR1. Activated in an LPA-dependent manner by LPAR1 and in an LPA-independent manner by LPAR2. Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase- activating protein (GAP). Belongs to the small GTPase superfamily. Ras family.
Protein type: G protein; G protein, monomeric, Ras; Motility/polarity/chemotaxis; G protein, monomeric
Chromosomal Location of Human Ortholog: 7p15-p13
Cellular Component: cell surface; focal adhesion; cytoplasmic vesicle membrane; endocytic vesicle; plasma membrane; midbody; cleavage furrow
Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; myosin binding; Edg-2 lysophosphatidic acid receptor binding; ubiquitin protein ligase binding; ATPase binding
Biological Process: positive regulation of filopodium formation; regulation of exocytosis; exocytosis; lipid raft localization; nerve growth factor receptor signaling pathway; viral reproduction; metabolic process; Ras protein signal transduction; actin cytoskeleton reorganization; cytokinesis; signal transduction; chemotaxis
Research Articles on RALA
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Product Notes
The RALA rala (Catalog #AAA9204141) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 158-186. The RALA Antibody (C-term) reacts with Human (Predicted Reactivity: Mouse, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's RALA can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the RALA rala for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RALA, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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