Rabbit HOXC8 Polyclonal Antibody | anti-HOXC8 antibody

HOXC8 Polyclonal Antibody

Cat. Num. AAA3006889

• Gene Names: HOXC8; HOX3; HOX3A
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: HOXC8; Polyclonal Antibody; HOXC8 Polyclonal Antibody; Homeobox protein Hox-C8; Homeobox protein Hox-3A; HOX3A; anti-HOXC8 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: HOXC8 polyclonal antibody detects endogenous levels of HOXC8 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 242

• Applicable Applications for anti-HOXC8 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human HOXC8
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of HOXC8 polyclonal antibody at 1:500 dilutionLane1:HEK293T whole cell lysateLane2:Raw264. 7 whole cell lysate Lane3:PC12 whole cell lysate)

Related Product Information for anti-HOXC8 antibody

HoxC8 (Homeobox protein Hox-C8, Hox-3A) is a 242 amino acid protein encoded by the human gene HOXC8. HoxC8 belongs to the Antp homeobox family and contains one homeobox DNA-binding domain. The Hox proteins play a role in development and cellular differentiation by regulating downstream target genes. Specifically, the Hox proteins direct DNA-protein and protein-protein interactions that assist in determining the morphologic features associated with the anterior-posterior body axis. Homeobox region 3 contains at least seven homeoboxes within 160 kb of DNA. Overexpression of the HOXC8 transgene causes cartilage defects, the severity of which depends upon transgene dosage. This abnormal cartilage is characterized by an accumulation of proliferating chondrocytes and reduced maturation. Since HoxC8 is normally expressed in chondrocytes, it may be responsible for skeletal development other than pattern formation in a tissue-specific manner, hypothetically by controlling the progression of cells along the chondrocyte differentiation pathway.

NCBI and Uniprot Product Information

• NCBI GI #: 13124745
• NCBI GeneID: 3224
• UniProt Accession #: P31273
• Molecular Weight: ~ 28kDa
• NCBI Official Full Name: Homeobox protein Hox-C8
• NCBI Official Synonym Full Names: homeobox C8
• NCBI Official Symbol: HOXC8
• NCBI Official Synonym Symbols: HOX3; HOX3A
• NCBI Protein Information: homeobox protein Hox-C8
• UniProt Protein Name: Homeobox protein Hox-C8
• Protein Family: Homeobox protein
• UniProt Gene Name: HOXC8
• UniProt Synonym Gene Names: HOX3A
• UniProt Entry Name: HXC8_HUMAN

NCBI Description

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders. [provided by RefSeq, Jul 2008]

Uniprot Description

HOXC8: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Antp homeobox family.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 12q13.3

Cellular Component: microtubule cytoskeleton; nucleoplasm

Molecular Function: sequence-specific DNA binding; transcription factor activity

Biological Process: neuron differentiation; anterior/posterior pattern formation; transcription, DNA-dependent; skeletal morphogenesis; negative regulation of transcription from RNA polymerase II promoter