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Western Blot (WB) (Western blot analysis of RAIDD in HeLa total cell lysate with RAIDD antibody at 1 ug/mL.)

Rabbit anti-Human RAIDD Polyclonal Antibody | anti-RAIDD antibody

RAIDD Antibody

Gene Names
CRADD; MRT34; RAIDD
Reactivity
Human
Applications
ELISA, Western Blot, Immunohistochemistry
Purity
DEAE purified
Synonyms
RAIDD; Polyclonal Antibody; RAIDD Antibody; CRADD; anti-RAIDD antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Purity/Purification
DEAE purified
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
199
Applicable Applications for anti-RAIDD antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Immunogen Type
Peptide
Immunogen Description
Raised against a peptide corresponding to amino acids near the carboxy terminus of human RAIDD.
Target Name
RAIDD
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of RAIDD in HeLa total cell lysate with RAIDD antibody at 1 ug/mL.)

Western Blot (WB) (Western blot analysis of RAIDD in HeLa total cell lysate with RAIDD antibody at 1 ug/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of RAIDD in human kidney tissue with RAIDD antibody at 10 ug/mL.)

Immunohistochemistry (IHC) (Immunohistochemistry of RAIDD in human kidney tissue with RAIDD antibody at 10 ug/mL.)
Related Product Information for anti-RAIDD antibody
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain (DD)-containing receptors, TNFR1 and Fas. The death signals are transduced by a group of DD-containing adapter molecules. A novel cell death adapter was recently identified by two independent groups and designated RAIDD (RIP-associated ICH-1/CED-3-homologous protein with DD) and CRADD (caspase and RIP adapter with DD)1, RAIDD contains a DD and a CARD (for caspase recruitment domain) which interact with RIP and caspase, respectively, to transduce death signals. RAIDD is constitutively expressed in many tissues and mediates apoptosis caused by Fas and TNFR-1.
Product Categories/Family for anti-RAIDD antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
Molecular Weight
11,826 Da
NCBI Official Full Name
death adaptor molecule RAIDD
NCBI Official Synonym Full Names
CASP2 and RIPK1 domain containing adaptor with death domain
NCBI Official Symbol
CRADD
NCBI Official Synonym Symbols
MRT34; RAIDD
NCBI Protein Information
death domain-containing protein CRADD
UniProt Protein Name
Death domain-containing protein CRADD
UniProt Gene Name
CRADD
UniProt Synonym Gene Names
RAIDD
UniProt Entry Name
CRADD_HUMAN

NCBI Description

The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins. [provided by RefSeq, Jul 2008]

Uniprot Description

CRADD: Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex. Defects in CRADD are the cause of mental retardation autosomal recessive type 34 (MRT34). A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRT34 is a non- syndromic form. Affected individuals have mildly delayed development and significantly impaired cognitive function, precluding independent living and self-care. Speech is rudimentary, but articulate; autism is not present.

Protein type: Adaptor/scaffold; Apoptosis

Chromosomal Location of Human Ortholog: 12q21.33-q23.1

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding, bridging; protein binding; protease binding

Biological Process: caspase activation; induction of apoptosis via death domain receptors; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

Disease: Mental Retardation, Autosomal Recessive 34

Research Articles on RAIDD

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Product Notes

The RAIDD cradd (Catalog #AAA9402906) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RAIDD Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's RAIDD can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the RAIDD cradd for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RAIDD, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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