Rabbit PTPRE / PTP Epsilon Polyclonal Antibody | anti-PTPRE antibody

Rabbit Polyclonal to Human PTPRE / PTP Epsilon

Cat. Num. AAA243846

• Gene Names: PTPRE; PTPE; HPTPE; R-PTP-EPSILON
• Reactivity: Bat, Gibbon, Bovine, Chicken, Dog, Hamster, Horse, Human, Monkey; Predicted Reactivity: Mouse, Rat, Xenopus, Zebrafish (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: PTPRE / PTP Epsilon; Polyclonal Antibody; Rabbit Polyclonal to Human PTPRE / PTP Epsilon; Anti-PTPRE / PTP Epsilon Antibody (Cytoplasmic Domain) IHC-plus; PTPRE; HPTPE; PTPE; Ptpepsilon; R-PTP-EPSILON; PTPvarepsilon; PTP epsilon; Human PTPRE; PTP Epsilon; anti-PTPRE antibody

• Host: Rabbit
• Reactivity: Bat, Gibbon, Bovine, Chicken, Dog, Hamster, Horse, Human, Monkey; Predicted Reactivity: Mouse, Rat, Xenopus, Zebrafish (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human PTPRE. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except PTPRA (67%).
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 700

• Applicable Applications for anti-PTPRE antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (3 - 6 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 18 amino acid peptide from cytoplasmic domain of human PTPRE. Percent identity with other species by BLAST analysis: Human, Gibbon (100%); Monkey (94%); Marmoset, Rat, Hamster, Panda, Dog, Bovine (89%); Mouse, Horse (83%).
• Immunogen Type: Synthetic peptide
• Immunogen: PTPRE / PTP Epsilon antibody was raised against synthetic 18 amino acid peptide from cytoplasmic domain of human PTPRE. Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Hamster, Elephant, Panda, Dog, Bat, Bovine, Horse, Opossum, Turkey, Chicken, Platypus, Lizard (100%); Mouse, Rat, Xenopus, Zebrafish (94%); Seabass, Pufferfish (89%); Stickleback, Medaka (83%).
• Antigen Modification: Cytoplasmic Domain
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-PTPRE antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 3-6 ug/ml.)

Immunohistochemistry (IHC)

(Anti-PTPRE antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 3-6 ug/ml.)

Related Product Information for anti-PTPRE antibody

PTP epsilon, an R4 receptor protein tyrosine phosphatase, is composed of a short extracellular and two cytoplasmic protein phosphatase domains and has been shown to affect neuronal differentiation, endothelial cell growth, vascular development, and possibly mammary tumor development. It has been shown that the cytosolic form of PTP epsilon can be induced by IL-1 and TNF alpha in humans and is a negative regulator of IL-6- and LIF-induced Jak-STAT kinase signaling in rats.

Product Categories/Family for anti-PTPRE antibody

Family: Protein Phosphatase; Subfamily: R4

NCBI and Uniprot Product Information

• NCBI GI #: 5729993
• NCBI GeneID: 5791
• NCBI Accession #: NP_006495.1
• NCBI GenBank Nucleotide #: NM_006504.4
• UniProt Accession #: P23469; Q13345; Q5VWH3; Q5VWH4; Q96KQ6
• Molecular Weight: 71,382 Da
• NCBI Official Full Name: receptor-type tyrosine-protein phosphatase epsilon isoform 1
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, receptor type, E
• NCBI Official Symbol: PTPRE
• NCBI Official Synonym Symbols: PTPE; HPTPE; R-PTP-EPSILON
• NCBI Protein Information: receptor-type tyrosine-protein phosphatase epsilon; protein tyrosine phosphatase, receptor type, epsilon polypeptide
• UniProt Protein Name: Receptor-type tyrosine-protein phosphatase epsilon
• Protein Family: Receptor-type tyrosine-protein phosphatase
• UniProt Gene Name: PTPRE
• UniProt Synonym Gene Names: Protein-tyrosine phosphatase epsilon; R-PTP-epsilon
• UniProt Entry Name: PTPRE_HUMAN

NCBI Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq, Jul 2008]

Uniprot Description

PTPRE: a cytoplasmic and transmembrane receptor protein tyrosine phosphatase that regulates IL-10 and TNFA biosynthesis, myelination and cell-matrix adhesion, overexpression reduces tumor development

Protein type: Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine; Membrane protein, integral; EC 3.1.3.48

Chromosomal Location of Human Ortholog: 10q26

Cellular Component: cytoplasm; integral to membrane; plasma membrane; nucleus

Molecular Function: protein binding; protein homodimerization activity; transmembrane receptor protein tyrosine phosphatase activity

Biological Process: negative regulation of insulin receptor signaling pathway; protein amino acid dephosphorylation; transmembrane receptor protein tyrosine phosphatase signaling pathway; regulation of mast cell activation