Rabbit anti-Human PTPRE Polyclonal Antibody | anti-PTPRE antibody

PTPRE Antibody

Cat. Num. AAA9409964

• Gene Names: PTPRE; PTPE; HPTPE; R-PTP-EPSILON
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: PTPRE; Polyclonal Antibody; PTPRE Antibody; PTPE; HPTPE; R-PTP-EPSILON; anti-PTPRE antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total PTPRE protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 0.4 mg/ml (varies by lot)
• Sequence Length: 700

• Applicable Applications for anti-PTPRE antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:15-1:50
• Immunogen Type: Recombinant Protein
• Immunogen Description: Fusion protein corresponding to a region derived from internal residues of human protein tyrosine phosphatase, receptor type, E
• Target Name: PTPRE
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human ovarian cancer tissue using at dilution 1/10.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue using at dilution 1/10.)

Related Product Information for anti-PTPRE antibody

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels.

Product Categories/Family for anti-PTPRE antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 5729993
• NCBI GeneID: 5791
• NCBI Accession #: NP_006495.1
• NCBI GenBank Nucleotide #: NM_006504.4
• UniProt Accession #: P23469; Q13345; Q5VWH3; Q5VWH4; Q96KQ6
• Molecular Weight: 71,382 Da
• NCBI Official Full Name: receptor-type tyrosine-protein phosphatase epsilon isoform 1
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, receptor type, E
• NCBI Official Symbol: PTPRE
• NCBI Official Synonym Symbols: PTPE; HPTPE; R-PTP-EPSILON
• NCBI Protein Information: receptor-type tyrosine-protein phosphatase epsilon
• UniProt Protein Name: Receptor-type tyrosine-protein phosphatase epsilon
• Protein Family: Receptor-type tyrosine-protein phosphatase
• UniProt Gene Name: PTPRE
• UniProt Synonym Gene Names: Protein-tyrosine phosphatase epsilon; R-PTP-epsilon
• UniProt Entry Name: PTPRE_HUMAN

NCBI Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq, Jul 2008]

Uniprot Description

PTPRE: a cytoplasmic and transmembrane receptor protein tyrosine phosphatase that regulates IL-10 and TNFA biosynthesis, myelination and cell-matrix adhesion, overexpression reduces tumor development

Protein type: Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine; EC 3.1.3.48; Membrane protein, integral

Chromosomal Location of Human Ortholog: 10q26

Cellular Component: cytoplasm; plasma membrane; integral to membrane; nucleus

Molecular Function: protein binding; protein homodimerization activity; transmembrane receptor protein tyrosine phosphatase activity

Biological Process: negative regulation of insulin receptor signaling pathway; protein amino acid dephosphorylation; transmembrane receptor protein tyrosine phosphatase signaling pathway; regulation of mast cell activation