60S ribosomal protein L27 Recombinant Protein | C1D recombinant protein

Recombinant human 60S ribosomal protein L27 protein

Cat. Num. AAA717283

• Gene Names: C1D; LRP1; hC1D; SUNCOR; SUN-CoR
• Applications: SDS-Page, ELISA, Western Blot
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: 60S ribosomal protein L27; Recombinant human 60S ribosomal protein L27 protein; C1D recombinant protein

• Host: E Coli
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Liquid containing glycerol
• Sequence: GKFMKPGKVVLVLAGRYSGRKAVIVKNIDDGTSDRPYSHALVAGIDRYPRKVTAAMGKKKIAKRSKIKSFVKVYNYNHLMPTRYSVDIPLDKTVVNKDVFRDPALKRKARREAKVKFEERYKTGKNKWFFQKLRF

• Applicable Applications for C1D recombinant protein: SDS-PAGE, ELISA (EIA), Western Blot (WB)
• Preparation and Storage: Store at -20 degree C. For extended storage,conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for C1D recombinant protein

Belongs to the ribosomal protein L27e family.

NCBI and Uniprot Product Information

• NCBI GI #: 223468650
• NCBI GeneID: 10438
• NCBI Accession #: NP_006324.1
• NCBI GenBank Nucleotide #: NM_006333.3
• UniProt Accession #: Q13901; Q05D64; A8K336; D6W5F8
• Molecular Weight: 42 KD
• NCBI Official Full Name: Homo sapiens C1D nuclear receptor corepressor (C1D), transcript variant 1, mRNA
• NCBI Official Synonym Full Names: C1D nuclear receptor corepressor
• NCBI Official Symbol: C1D
• NCBI Official Synonym Symbols: LRP1; hC1D; SUNCOR; SUN-CoR
• NCBI Protein Information: nuclear nucleic acid-binding protein C1D; C1D DNA-binding protein; nuclear DNA-binding protein; C1D nuclear receptor co-repressor; small unique nuclear receptor corepressor; small unique nuclear receptor co-repressor
• UniProt Protein Name: Nuclear nucleic acid-binding protein C1D
• Protein Family: 60S ribosomal protein
• UniProt Gene Name: C1D
• UniProt Synonym Gene Names: hC1D
• UniProt Entry Name: C1D_HUMAN

NCBI Description

The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10.[provided by RefSeq, Jun 2010]

Uniprot Description

Function: Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB

By similarity. Ref.6 Ref.8 Ref.9 Ref.10

Subunit structure: Monomer and homodimer. Interacts with NR1D1, THRA, THRB, NCOR1 and NCOR2

By similarity. Interacts with EXOSC10; the interaction probably mediates the association with the nuclear form of the RNA exosome. The homodimeric form interacts with TSNAX following gamma-radiation. Interacts with RAC3. Ref.1 Ref.6 Ref.7 Ref.9 Ref.10

Subcellular location: Cytoplasm. Nucleus › nucleolus. Note: EXOSC10 is required for nucleolar localization. Ref.9 Ref.10

Tissue specificity: Ubiquitous. Expressed at very high levels in the hippocampus, medulla oblongata, mammary gland, thyroid and salivary gland. Expressed at high levels in the fetal; lung, liver and kidney. Expressed at low levels in skeletal muscle, appendix, heart, lung and colon. Ref.8

Induction: By gamma-radiation. Ref.6

Post-translational modification: Phosphorylated by PRKDC. Ref.6

Sequence similarities: Belongs to the C1D family.