Western Blot (WB)
(PTPN2 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the PTPN2 antibody detected the PTPN2 protein (arrow).)
Rabbit anti-Human PTPN2 Polyclonal Antibody | anti-PTPN2 antibody
PTPN2 Antibody (C-term)
Western Blot (WB)
(PTPN2 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the PTPN2 antibody detected the PTPN2 protein (arrow).)
Western Blot (WB)
(PTPN2 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the PTPN2 antibody detected the PTPN2 protein (arrow).)
Immunohistochemistry (IHC)
(PTPN2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PTPN2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(PTPN2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PTPN2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
protein tyrosine phosphatase (PTP) family. Members of the PTP
family share a highly conserved catalytic motif, which is essential
for the catalytic activity. PTPs are known to be signaling
molecules that regulate a variety of cellular processes including
cell growth, differentiation, mitotic cycle, and oncogenic
transformation. Epidermal growth factor receptor and the adaptor
protein Shc were reported to be substrates of this PTP, which
suggested the roles in growth factor mediated cell signaling. Three
alternatively spliced variants of this gene, which encode isoforms
differing at their extreme C-termini, have been described. The
different C-termini are thought to determine the substrate
specificity, as well as the cellular localization of the isoforms.
Two highly related but distinctly processed pseudogenes that
localize to distinct chromosomes have been reported. [provided by
RefSeq].
Morgan, A.R., et al. Tissue Antigens 76(2):119-125(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Kleppe, M., et al. Nat. Genet. 42(6):530-535(2010)
Amre, D.K., et al. Aliment. Pharmacol. Ther. 31(11):1186-1191(2010)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]
Uniprot Description
PTPN2: a type 2 non-receptor phospho-tyrosine-protein phosphatase (PTP). Two alternatively spliced isoforms are differenyially expressed. Isoform A is a major PTP expressed in human tissues, while isoform B is expressed mainly in T-cells and in placenta.
Protein type: Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of Human Ortholog: 18p11.3-p11.2
Cellular Component: nucleoplasm; endoplasmic reticulum; plasma membrane; ER-Golgi intermediate compartment; nucleus
Molecular Function: integrin binding; protein binding; syntaxin binding; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; protein kinase binding
Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of tyrosine phosphorylation of Stat1 protein; cytokine and chemokine mediated signaling pathway; negative regulation of insulin receptor signaling pathway; negative regulation of T cell receptor signaling pathway; negative regulation of tyrosine phosphorylation of Stat5 protein; negative regulation of chemotaxis; glucose homeostasis; positive regulation of gluconeogenesis; negative regulation of cell proliferation; negative regulation of macrophage differentiation; negative regulation of inflammatory response; B cell differentiation; insulin receptor signaling pathway; negative regulation of tyrosine phosphorylation of Stat3 protein; negative regulation of tyrosine phosphorylation of Stat6 protein; erythrocyte differentiation; T cell differentiation
Research Articles on PTPN2
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Product Notes
The PTPN2 ptpn2 (Catalog #AAA9203130) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 329-358. The PTPN2 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PTPN2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB). WB~~1:1000. Researchers should empirically determine the suitability of the PTPN2 ptpn2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PTPN2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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