Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using at dilution 1/25,)
Rabbit anti-Human PRTFDC1 Polyclonal Antibody | anti-PRTFDC1 antibody
PRTFDC1 Antibody
Gene Names
PRTFDC1; HHGP
Reactivity
Human
Applications
Immunohistochemistry
Purity
Antigen Affinity Purification
Synonyms
PRTFDC1; Polyclonal Antibody; PRTFDC1 Antibody; HHGP; anti-PRTFDC1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
The antibody detects endogenous levels of total PRTFDC1 protein.
Purity/Purification
Antigen Affinity Purification
Form/Format
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Concentration
0.7 mg/ml (varies by lot)
Sequence Length
190
Applicable Applications for anti-PRTFDC1 antibody
Immunohistochemistry (IHC)
Immunogen
Full length fusion protein of human PRTFDC1
Immunogen Type
Protein
Preparation and Storage
Store at -20 degree C
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using at dilution 1/25,)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using at dilution 1/25,)
Related Product Information for anti-PRTFDC1 antibody
PRTFDC1 (phosphoribosyltransferase domain-containing protein 1), also known as HHGP, is a 225 amino acid protein that belongs to the purine/pyrimidine phosphoribosyltransferase family. The functions of PRTFCD1 are not well understood; however it has been suggested that it is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation. Conserved in vertebrates, PRTFDC1 is suggested to be a possible tumor-suppressor. PRTFDC1 is encoded by a gene which maps to chromosome 10. Spanning nearly 135 million base pairs, chromosome 10 makes up approximately 4.5% of the total DNA in cells and encodes nearly 1,200 genes.Three isoformsof PRTFDC1 exist due to alternative splicing events. Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). Is not expected to contribute to purine metabolism or GMP salvage.
Product Categories/Family for anti-PRTFDC1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
19,983 Da
NCBI Official Full Name
phosphoribosyltransferase domain-containing protein 1 isoform 2
NCBI Official Synonym Full Names
phosphoribosyl transferase domain containing 1
NCBI Official Symbol
PRTFDC1
NCBI Official Synonym Symbols
HHGP
NCBI Protein Information
phosphoribosyltransferase domain-containing protein 1
UniProt Protein Name
Phosphoribosyltransferase domain-containing protein 1
Protein Family
UniProt Gene Name
PRTFDC1
UniProt Synonym Gene Names
HHGP
UniProt Entry Name
PRDC1_HUMAN
Uniprot Description
PRTFDC1: Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). Is not expected to contribute to purine metabolism or GMP salvage. Belongs to the purine/pyrimidine phosphoribosyltransferase family. 3 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 10p12.1
Cellular Component: cytosol
Molecular Function: hypoxanthine phosphoribosyltransferase activity; magnesium ion binding; protein binding; protein homodimerization activity
Biological Process: adenine salvage; GMP catabolic process; GMP salvage; guanine salvage; hypoxanthine metabolic process; IMP salvage
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Product Notes
The PRTFDC1 prtfdc1 (Catalog #AAA9416402) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PRTFDC1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PRTFDC1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the PRTFDC1 prtfdc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PRTFDC1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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