Western Blot (WB)
(Western blot analysis of PRTFDC1 in human brain tissue lysate with PRTFDC1 antibody at 1 ug/mL in the (A) absence and (B) presence of blocking peptide.)
Rabbit PRTFDC1 Polyclonal Antibody | anti-PRTFDC1 antibody
PRTFDC1 Antibody
Gene Names
PRTFDC1; HHGP
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot
Purity
Affinity chromatography purified via peptide column
Synonyms
PRTFDC1; Polyclonal Antibody; PRTFDC1 Antibody; Phosphoribosyl transferase domain containing 1; HHGP; anti-PRTFDC1 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
225
Applicable Applications for anti-PRTFDC1 antibody
ELISA (EIA), Western Blot (WB)
Immunogen Type
Peptide
Immunogen Description
Raised against a 14 amino acid peptide from near the center of human PRTFDC1.
Target Name
PRTFDC1
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Western Blot (WB)
(Western blot analysis of PRTFDC1 in human brain tissue lysate with PRTFDC1 antibody at 1 ug/mL in the (A) absence and (B) presence of blocking peptide.)
Western Blot (WB)
(Western blot analysis of PRTFDC1 in human brain tissue lysate with PRTFDC1 antibody at 1 ug/mL in the (A) absence and (B) presence of blocking peptide.)
Related Product Information for anti-PRTFDC1 antibody
Phosphoribosyl transferase domain containing 1 (PRTFDC1) is highly homologous to the hypoxanthine phosphoribosyltransferase (HPRT1) and may have arisen from a gene duplication event of a common ancestor gene. Recently, it was shown that CpG islands in the PRTFDC1 promoter could be hypermethylated in ovarian cancers and oral squamous-cell carcinomas (OSCC), leading to gene silencing. Restoration of PRTFDC1 expression in OSCC inhibited cell growth in colony-formation assays, while knockdown of PRTFDC1 expression in OSCC that expressed the gene promoted cell growth. These results suggest that PRTFDC1 can act as a tumor-suppressor gene. At least three isoforms of PRTFDC1 are known to exist.
Product Categories/Family for anti-PRTFDC1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
19,983 Da
NCBI Official Full Name
phosphoribosyltransferase domain-containing protein 1 isoform 1
NCBI Official Synonym Full Names
phosphoribosyl transferase domain containing 1
NCBI Official Symbol
PRTFDC1
NCBI Official Synonym Symbols
HHGP
NCBI Protein Information
phosphoribosyltransferase domain-containing protein 1
UniProt Protein Name
Phosphoribosyltransferase domain-containing protein 1
Protein Family
UniProt Gene Name
PRTFDC1
UniProt Synonym Gene Names
HHGP
UniProt Entry Name
PRDC1_HUMAN
Uniprot Description
PRTFDC1: Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). Is not expected to contribute to purine metabolism or GMP salvage. Belongs to the purine/pyrimidine phosphoribosyltransferase family. 3 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 10p12.1
Cellular Component: cytosol
Molecular Function: protein homodimerization activity; magnesium ion binding; nucleotide binding; hypoxanthine phosphoribosyltransferase activity
Biological Process: GMP catabolic process; hypoxanthine metabolic process; IMP salvage; GMP salvage; adenine salvage; purine ribonucleoside salvage; guanine salvage
Research Articles on PRTFDC1
Similar Products
Product Notes
The PRTFDC1 prtfdc1 (Catalog #AAA9408116) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PRTFDC1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PRTFDC1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the PRTFDC1 prtfdc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PRTFDC1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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