Rabbit anti-Human PROZ Polyclonal Antibody | anti-PROZ antibody

PROZ (Vitamin K-dependent Protein Z, PZ) (Biotin)

Cat. Num. AAA6390958

• Gene Names: PROZ; PZ
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: PROZ; Polyclonal Antibody; PROZ (Vitamin K-dependent Protein Z; PZ) (Biotin); anti-PROZ antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human PROZ.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-PROZ antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human PROZ, aa1-400 (NP_003882.1).
• Immunogen Sequence: MAGCVPLLQGLVLVLALHRVEPSVFLPASKANDVLVRWKRAGSYLLEELFEGNLEKECYEEICVYEEAREVFENEVVTDEFWRRYKGGSPCISQPCLHNGSCQDSIWGYTCTCSPGYEGSNCELAKNECHPERTDGCQHFCLPGQESYTCSCAQGYRLGEDHKQCVPHDQCACGVLTSEKRAPDLQDLPWQVKLTNSEGKDFCGGVIIRENFVLTTAKCSLLHRNITVKTYFNRTSQDPLMIKITHVHVHMRYDADAGENDLSLLELEWPIQCPGAGLPVCTPEKDFAEHLLIPRTRGLLSGWARNGTDLGNSLTTRPVTLVEGEECGQVLNVTVTTRTYCERSSVAAMHWMDGSVVTREHRGSWFLTGVLGSQPVGGQAHMVLVTKVSRYSLWFKQIMN
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of PROZ expression in transfected 293T cell line by PROZ polyclonal antibody. Lane 1: PROZ transfected lysate (44.7kD). Lane 2: Non-transfected lysate.)

Product Categories/Family for anti-PROZ antibody

Antibodies; Carbohydrates; Glycoproteins

NCBI and Uniprot Product Information

• NCBI GI #: 4506121
• NCBI GeneID: 8858
• NCBI Accession #: NP_003882.1
• NCBI GenBank Nucleotide #: NM_003891
• UniProt Accession #: P22891; Q15213; Q5JVF5; Q5JVF6; A6NMB4
• Molecular Weight: 47,053 Da
• NCBI Official Full Name: vitamin K-dependent protein Z isoform 2
• NCBI Official Synonym Full Names: protein Z, vitamin K-dependent plasma glycoprotein
• NCBI Official Symbol: PROZ
• NCBI Official Synonym Symbols: PZ
• NCBI Protein Information: vitamin K-dependent protein Z
• UniProt Protein Name: Vitamin K-dependent protein Z
• Protein Family: Vitamin K-dependent protein
• UniProt Gene Name: PROZ
• UniProt Entry Name: PROZ_HUMAN

NCBI Description

This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Uniprot Description

PROZ: Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: Golgi lumen; endoplasmic reticulum lumen

Molecular Function: serine-type endopeptidase activity; calcium ion binding

Biological Process: cellular protein metabolic process; blood coagulation; post-translational protein modification; proteolysis; peptidyl-glutamic acid carboxylation

Disease: Protein Z Deficiency