C1D recombinant protein

Recombinant Human C1D Protein (GST tag)

Cat. Num. AAA2545512

• Gene Names: C1D; LRP1; hC1D; Rrp47; SUNCOR; SUN-CoR
• Purity: > 80 % as determined by SDS-PAGE
• Synonyms: C1D; Recombinant Human C1D Protein (GST tag); LRP1; MGC12261; MGC14659; SUN-CoR; SUNCOR; Hc1d; C1D recombinant protein

• Host: E Coli
• Purity/Purification: > 80 % as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH 7.5
• Sequence Length: 141

• Application Notes: The recombinant human C1D/GST chimera consists of 375 amino acids and has a predicted molecular mass of 43.2 kDa. It migrates as an approximately 43 KDa band in SDS-PAGE under reducing conditions.
• Predicted N Terminal: Met
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -70 degree C

SDS-PAGE

Related Product Information for C1D recombinant protein

Background: C1D nuclear receptor corepressor belongs to the C1D family. It is a DNA binding and apoptosis-inducing protein.C1D nuclear receptor corepressorinteracts with TSNAX and DNA-PKcs. It acts as a corepressor for the thyroid hormone receptor. It is thought that C1D nuclear receptor corepressor regulates TRAX/Translin complex formation. It is expressed in kidney, heart, brain, spleen, lung, testis, liver and small intestine. It plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. It potentiates transcriptional repression by NR1D1 and THRB. C1D nuclear receptor corepressorcan activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. It also can induce apoptosis in a p53/TP53 dependent manner.

Description: A DNA sequence encoding the human C1D (Q13901) (Met 1-Ser 141) was fused with the GST tag at the N-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 298231253
• NCBI GeneID: 10438
• NCBI Accession #: NP_001177192.1
• NCBI GenBank Nucleotide #: NM_001190263.1
• UniProt Accession #: Q13901; Q05D64; A8K336; D6W5F8
• Molecular Weight: 16,019 Da
• NCBI Official Full Name: nuclear nucleic acid-binding protein C1D
• NCBI Official Synonym Full Names: C1D nuclear receptor corepressor
• NCBI Official Symbol: C1D
• NCBI Official Synonym Symbols: LRP1; hC1D; Rrp47; SUNCOR; SUN-CoR
• NCBI Protein Information: nuclear nucleic acid-binding protein C1D
• UniProt Protein Name: Nuclear nucleic acid-binding protein C1D
• Protein Family: Nuclear nucleic acid-binding protein
• UniProt Gene Name: C1D
• UniProt Synonym Gene Names: hC1D

NCBI Description

The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10.[provided by RefSeq, Jun 2010]

Uniprot Description

C1D: Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB. Belongs to the C1D family.

Protein type: DNA-binding; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 2p14

Cellular Component: nuclear exosome (RNase complex); nucleolus; nucleoplasm; nucleus

Molecular Function: protein binding; RNA binding

Biological Process: maturation of 5.8S rRNA; rRNA processing