Mouse anti-Human PROZ / Protein Z Monoclonal Antibody | anti-PROZ antibody

Mouse Monoclonal [clone 2B4] (IgG1) to Human PROZ / Protein Z

Cat. Num. AAA245559

• Gene Names: PROZ; PZ
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Ascites
• Synonyms: PROZ / Protein Z; Monoclonal Antibody; Mouse Monoclonal [clone 2B4] (IgG1) to Human PROZ / Protein Z; Anti-PROZ / Protein Z Antibody (clone 2B4) IHC-plus; PROZ; Vitamin K-dependent protein Z; Protein Z; PZ; Human PROZ; anti-PROZ antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 2B4
• Specificity: Human PROZ
• Purity/Purification: Ascites
• Form/Format: Ascites fluid, 0.03% sodium azide. Sourced in Ascites.
• Sequence Length: 400

• Applicable Applications for anti-PROZ antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA (1:10000), IHC-P (1:200 - 1:400), WB (1:500 - 1:2000)
• Target Species: Human
• Immunogen Description: Purified recombinant fragment of PROZ expressed in E Coli.
• Immunogen: PROZ / Protein Z antibody was raised against purified recombinant fragment of PROZ expressed in E Coli.
• Preparation and Storage: Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.

Immunohistochemistry (IHC)

(Anti-PROZ antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.)

Immunohistochemistry (IHC)

(Anti-PROZ antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.)

Immunohistochemistry (IHC)

(Anti-PROZ antibody IHC of human small intestine, vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.)

Western Blot (WB)

(Western blot of anti-PROZ monoclonal antibody against human plasma (1).)

NCBI and Uniprot Product Information

• NCBI GI #: 4506121
• NCBI GeneID: 8858
• NCBI Accession #: NP_003882.1
• NCBI GenBank Nucleotide #: NM_003891.2
• UniProt Accession #: P22891; Q15213; Q5JVF5; Q5JVF6; A6NMB4
• Molecular Weight: 47,053 Da
• NCBI Official Full Name: vitamin K-dependent protein Z isoform 2
• NCBI Official Synonym Full Names: protein Z, vitamin K-dependent plasma glycoprotein
• NCBI Official Symbol: PROZ
• NCBI Official Synonym Symbols: PZ
• NCBI Protein Information: vitamin K-dependent protein Z
• UniProt Protein Name: Vitamin K-dependent protein Z
• Protein Family: Vitamin K-dependent protein
• UniProt Gene Name: PROZ
• UniProt Entry Name: PROZ_HUMAN

NCBI Description

This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Uniprot Description

PROZ: Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: Golgi lumen; endoplasmic reticulum lumen

Molecular Function: serine-type endopeptidase activity; calcium ion binding

Biological Process: cellular protein metabolic process; proteolysis; blood coagulation; post-translational protein modification; peptidyl-glutamic acid carboxylation

Disease: Protein Z Deficiency