Rabbit Prostaglandin E Synthase-1, microsomal Polyclonal Antibody | anti-PTGES antibody

Prostaglandin E Synthase-1, microsomal (mPGES-1, Membrane-associated PGES-1, mPGE synthase-1, Prostaglandin H/E isomerase, PIG12, MGST1-L1)

Cat. Num. AAA626077

• Gene Names: PTGES; PGES; MPGES; PIG12; PP102; PP1294; MGST-IV; MGST1L1; TP53I12; mPGES-1; MGST1-L1
• Reactivity: Human, Mouse, Rat, Sheep
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Prostaglandin E Synthase-1; microsomal; Polyclonal Antibody; microsomal (mPGES-1; Membrane-associated PGES-1; mPGE synthase-1; Prostaglandin H/E isomerase; PIG12; MGST1-L1); Anti -Prostaglandin E Synthase-1; anti-PTGES antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat, Sheep
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human microsomal PGE synthase-1. Species Crossreactivity: mouse, rat and sheep
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in TBS, pH 7.4, containing 50% glycerol, 0.5mg/ml BSA, and 0.02% sodium azide.

• Applicable Applications for anti-PTGES antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Immunohistochemistry and Western Blot.; Dilution: Immunohistochemistry: 1:125-1:250; Western Blot: 1:250; Optimal dilution to be determined by the researcher.
• Immunogen: Synthetic peptide corresponding to aa59-75 (CRSDPDVERSLRAHRND) of human microsomal PGE synthase-1
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(Western Blot of MBS626077)

Related Product Information for anti-PTGES antibody

The prostanoid family includes PGD2, PGE2, PGF2alpha, PGI2, thromboxane A2 and prostaglandins. The prostaglandins (PGs) are implicated in various physiological and pathophysiological events, including male fertility, menstruation, ovulation, pregnancy, implantation and inflamatory and neoplastic diseases. The biosynthesis of PGs and some other prostanoids, is catalyzed in a rate limiting step by PG-H synthase (also known as cyclooxygenase (COX), PG-endoperoxidase synthase (PTGS)) which converts arachiodonic acid to prostaglandin/prostanoid precursor PGH2. Two cyclooxygenase isozymes, COX1 (human, 576aa, 69-72kD; chromosome 9) and COX2 (human, 604aa, 74kD; chromosome 1) have been identified. COX1, a constitutively expressed isoform, produces physiologically relevant prostanoids such as those in stomach and platelets. COX2 isoform is inducible and rapidly upregulated at inflamation sites and forms proinflamatory prostanoids. The overexpression of COX-2 also leads to tumerogenesis. Recently, a third isoform COX3 (canine 633aa; ~65kD in human aorta) has been reported. Two smaller COX1-derived proteins (partial COX1) PCOX1a (canine 414aa, ~53kDa in human aorta) and PCOX1b have also been characterized. The COX3, but not PCOX1a, possesses glycosylation dependent cyclooxygenase activity. The nonsteroidal antiinflammatory drugs (NSAIDs) reduce the formation of prostaglandins by inhibiting the activity of cyclooxygenases (COX1, COX2 and COX3), This ability was associated with inhibition of COX, which converts arachidonic acid to the prostaglandin precursor prostaglandin H2.

Product Categories/Family for anti-PTGES antibody

Antibodies; Abs to Prostaglandins

NCBI and Uniprot Product Information

• NCBI GI #: 4758910
• NCBI GeneID: 9536
• NCBI Accession #: NP_004869.1
• NCBI GenBank Nucleotide #: NM_004878.4
• UniProt Accession #: O14684; O14900; Q5SZC0
• Molecular Weight: 17,102 Da
• NCBI Official Full Name: prostaglandin E synthase
• NCBI Official Synonym Full Names: prostaglandin E synthase
• NCBI Official Symbol: PTGES
• NCBI Official Synonym Symbols: PGES; MPGES; PIG12; PP102; PP1294; MGST-IV; MGST1L1; TP53I12; mPGES-1; MGST1-L1
• NCBI Protein Information: prostaglandin E synthase; MGST1-like 1; p53-induced gene 12 protein; p53-induced apoptosis protein 12; glutathione S-transferase 1-like 1; microsomal prostaglandin E synthase 1; microsomal prostaglandin E synthase-1; tumor protein p53 inducible protein 12; microsomal glutathione S-transferase 1-like 1
• UniProt Protein Name: Prostaglandin E synthase
• Protein Family: Prostaglandin E synthase
• UniProt Gene Name: PTGES
• UniProt Synonym Gene Names: MGST1L1; MPGES1; PGES; PIG12; MGST1-L1; MPGES-1
• UniProt Entry Name: PTGES_HUMAN

NCBI Description

The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]

Uniprot Description

PTGES: Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Belongs to the MAPEG family.

Protein type: Nuclear envelope; Isomerase; Membrane protein, integral; EC 5.3.99.3; Lipid Metabolism - arachidonic acid; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: endoplasmic reticulum membrane; membrane; perinuclear region of cytoplasm; nuclear envelope lumen; integral to membrane

Molecular Function: glutathione binding; prostaglandin-E synthase activity

Biological Process: negative regulation of cell proliferation; chronic inflammatory response; response to retinoic acid; response to cytokine stimulus; cyclooxygenase pathway; arachidonic acid metabolic process; response to lipopolysaccharide; prostaglandin biosynthetic process; signal transduction; response to calcium ion; response to organic cyclic substance; acute inflammatory response; prostaglandin metabolic process