Rabbit Prosapip1 Polyclonal Antibody | anti-ProSAPiP1 antibody

Prosapip1 Antibody

Cat. Num. AAA150189

• Gene Names: LZTS3; PROSAPIP1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: Prosapip1 Antibody is affinity chromatography purified via peptide column.
• Synonyms: Prosapip1; Polyclonal Antibody; Prosapip1 Antibody; PROSAPIP1; KIAA0552; Leucine zipper putative tumor suppressor 3; ProSAP-interacting protein 1; ProSAPiP1; ProSAPiP1 protein; anti-ProSAPiP1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Prosapip1 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 627

• Applicable Applications for anti-ProSAPiP1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: Prosapip1 antibody can be used for detection of Prosapip1 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
• Conjugate: Unconjugated
• Immunogen: Prosapip1 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human Prosapip1.
• Buffer: Prosapip1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: Prosapip1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of Prosapip1 in SK-N-SH cell lysate with Prosapip1 antibody at 1 μg/mL. )

Immunohistochemistry (IHC)

(Immunohistochemistry of Prosapip1 in rat brain tissue with Prosapip1 antibody at 2.5 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of Prosapip 1 in rat brain tissue with Prosapip 1 antibody at 20 μg/mL.)

Related Product Information for anti-ProSAPiP1 antibody

Prosapip1 Antibody: Prosapip1 is a binding partner of the postsynaptic density (PSD) protein ProSAP2/Shank3, a major scaffolding protein in excitatory brain synapses. Prosapip1 is thought to bind ProSAP2/Shank3 through ProSAP2/Shank3's PDZ domain and link it in turn to the Spine-associated Rap-Gap (SPAR). Prosapip1 shares significant homology with another PSD protein, PSD-Zip70, with both coding for a Fez1 domain that can be found in a total of four related protein, forming a novel family of scaffolding molecules termed 'Fezzins'. Recent studies show that Prosapip1 can be found in endocrine cells in which it is localized primarily in the hormone-storing compartment of these cells, suggesting that Prosapip1 may have other functions in non-neuronal cells.

NCBI and Uniprot Product Information

• NCBI GI #: 7662176
• NCBI GeneID: 9762
• NCBI Accession #: NP_055546
• NCBI GenBank Nucleotide #: NM_014731.2
• UniProt Accession #: O60299; Q8IXX8; A2A2Q7; D3DVX6
• Molecular Weight: 66,409 Da
• NCBI Official Symbol: LZTS3
• NCBI Official Synonym Symbols: PROSAPIP1
• NCBI Protein Information: leucine zipper putative tumor suppressor 3
• UniProt Protein Name: Leucine zipper putative tumor suppressor 3
• UniProt Gene Name: LZTS3
• UniProt Synonym Gene Names: KIAA0552; PROSAPIP1; ProSAPiP1
• UniProt Entry Name: LZTS3_HUMAN

Uniprot Description

PROSAPIP1: Belongs to the PROSAPIP1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: postsynaptic membrane; cytoskeleton; postsynaptic density; cytoplasm; cell junction