Rabbit Slitrk1 Polyclonal Antibody | anti-SLITRK1 antibody

Slitrk1 Antibody

Cat. Num. AAA151014

• Gene Names: SLITRK1; TTM; LRRC12
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: Slitrk1 Antibody is affinity chromatography purified via peptide column.
• Synonyms: Slitrk1; Polyclonal Antibody; Slitrk1 Antibody; TTM; LRRC12; KIAA1910; UNQ233/PRO266; SLIT and NTRK-like protein 1; Leucine-rich repeat-containing protein 12; SLIT and NTRK-like family; member 1; anti-SLITRK1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: This antibody is predicted to have no cross-reactivity to other Slitrk proteins.
• Purity/Purification: Slitrk1 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 696

• Applicable Applications for anti-SLITRK1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: Slitrk1 antibody can be used for detection of Slitrk1 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
• Conjugate: Unconjugated
• Immunogen: Slitrk1 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human Slitrk1.
• Buffer: Slitrk1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: Slitrk1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of Slitrk1 in human brain tissue lysate with Slitrk1 antibody at (A) 1 and (B) 2 μg/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of Slitrk1 in human brain tissue with Slitrk1 antibody at 2.5 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of slitrk1 in human brain tissue with slitrk1 antibody at 20 μg/mL.)

Related Product Information for anti-SLITRK1 antibody

Slitrk1 Antibody: SLIT and NTRK-like family 1 (Slitrk1) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk1 is expressed primarily in mature neurons. Overexpression of Slitrk1 in transfected neuronal cells induced unipolar neurites, while expression of the other Slitrk proteins inhibited neurite outgrowth, suggesting that these proteins are involved in the control of neurite outgrowth. While Slitrk1 variants have been suggested associated with Tourette's Syndrome, it is thought to play only a minor role if at all.

NCBI and Uniprot Product Information

• NCBI GI #: 40217817
• NCBI GeneID: 114798
• NCBI Accession #: NP_443142
• NCBI GenBank Nucleotide #: NM_052910.2
• UniProt Accession #: Q96PX8; Q5U5I6; Q96SF9
• Molecular Weight: 77,735 Da
• NCBI Official Full Name: SLIT and NTRK-like protein 1
• NCBI Official Synonym Full Names: SLIT and NTRK-like family, member 1
• NCBI Official Symbol: SLITRK1
• NCBI Official Synonym Symbols: TTM; LRRC12
• NCBI Protein Information: SLIT and NTRK-like protein 1; slit and trk like gene 1; leucine-rich repeat-containing protein 12
• UniProt Protein Name: SLIT and NTRK-like protein 1
• Protein Family: SLIT and NTRK-like protein
• UniProt Gene Name: SLITRK1
• UniProt Synonym Gene Names: KIAA1910; LRRC12
• UniProt Entry Name: SLIK1_HUMAN

NCBI Description

This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. However, the protein encoded by this gene lacks the region of homology to neurotrophin receptors. This protein is thought to be involved in neurite outgrowth. Mutations in this gene may be associated with Tourette syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Description

SLITRK1: Enhances neuronal dendrite outgrowth. Defects in SLITRK1 may be a cause of Gilles de la Tourette syndrome (GTS). GTS is a neurologic disorder manifested particularly by motor and vocal tics and associated with behavioral abnormalities. Defects in SLITRK1 may be a cause of trichotillomania (TTM). It is a neuropsychiatric disorder characterized by chronic, repetitive, or compulsive hair pulling resulting in noticeable hair loss. Affected individuals may develop physical complications and often have overlapping psychologic disorders, such as Gilles de la Tourette syndrome or obsessive-compulsive disorder. Belongs to the SLITRK family.

Protein type: Membrane protein, integral; Cell development/differentiation

Chromosomal Location of Human Ortholog: 13q31.1

Cellular Component: integral to membrane

Biological Process: axonogenesis; homeostatic process; multicellular organism growth; adult behavior

Disease: Gilles De La Tourette Syndrome; Trichotillomania