Rabbit anti-Human, mouse PLEKHA8 Polyclonal Antibody | anti-PLEKHA8 antibody

PLEKHA8 Antibody

Cat. Num. AAA7001644

• Gene Names: PLEKHA8; FAPP2
• Reactivity: Human, mouse
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified
• Synonyms: PLEKHA8; Polyclonal Antibody; PLEKHA8 Antibody; Pleckstrin homology domain-containing family A member 8; PH domain-containing family A member 8; FAPP2; Phosphatidylinositol-four-phosphate adapter protein 2; FAPP-2; Phosphoinositol 4-phosphate adapter protein 2; hFAPP2; Serologically defined breast cancer antigen NY-BR-86; anti-PLEKHA8 antibody

• Host: Rabbit
• Reactivity: Human, mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purified
• Form/Format: Liquid
• Sequence Length: 519

• Applicable Applications for anti-PLEKHA8 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Recommended dilution: WB:1:500-2000, IHC:1:20-1:200
• Immunogen: Recombinant human Pleckstrin homology domain-containing family A member 8 protein
• Conjugation: Non-conjugated
• Storage Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-162817
• Preparation and Storage: Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.

Western Blot (WB)

(Western blotAll lanes: PLEKHA8 antibody at 0.8ug/ml+ Mouse brain tissueGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 59,52,50 kDaObserved band size: 58 kDa)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human placenta tissue using MBS7001644 at dilution of 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7001644 at dilution of 1:100)

Related Product Information for anti-PLEKHA8 antibody

Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation.

NCBI and Uniprot Product Information

• NCBI GI #: 308153327
• NCBI GeneID: 84725
• NCBI Accession #: NP_001183955.1
• NCBI GenBank Nucleotide #: NM_001197026.1
• UniProt Accession #: Q96JA3; Q7Z5V8; Q9BU78; Q9H274; Q9H8Z7; B4DH00
• Molecular Weight: 49,462 Da
• NCBI Official Full Name: pleckstrin homology domain-containing family A member 8 isoform 1
• NCBI Official Synonym Full Names: pleckstrin homology domain containing A8
• NCBI Official Symbol: PLEKHA8
• NCBI Official Synonym Symbols: FAPP2
• NCBI Protein Information: pleckstrin homology domain-containing family A member 8
• UniProt Protein Name: Pleckstrin homology domain-containing family A member 8
• Protein Family: Pleckstrin homology domain-containing family
• UniProt Gene Name: PLEKHA8
• UniProt Synonym Gene Names: FAPP2; PH domain-containing family A member 8; FAPP-2; Phosphoinositol 4-phosphate adapter protein 2; hFAPP2
• UniProt Entry Name: PKHA8_HUMAN

Uniprot Description

PLEKHA8: Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 7p14.3

Cellular Component: membrane; trans-Golgi network

Molecular Function: glycolipid binding; glycolipid transporter activity

Biological Process: glycolipid transport; lipid transport; protein transport