Rabbit PKC Gamma Polyclonal Antibody | anti-PKCG antibody

PKC Gamma Antibody

Cat. Num. AAA5312629

• Gene Names: Prkcg; PKC; PKCI; Prkc; Prkcc; RATPKCI
• Applications: Western Blot
• Purity: Affinity Chromatography
• Synonyms: PKC Gamma; Polyclonal Antibody; PKC Gamma Antibody; Affinity Purified Rabbit Polyclonal PKC gamma Antibody; Polyclonal PKC gamma antibody; Anti-PKC gamma antibody; Protein Kinase C gamma antibody; PKC antibody; anti-PKCG antibody

• Host: Rabbit
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Chromatography
• Form/Format: Lyophilized Form
• Sequence Length: 697

• Applicable Applications for anti-PKCG antibody: Western Blot (WB)
• Immunogen: PKC gamma antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the C-terminal of human PKC gamma, identical to the related rat and Rabbit sequence as the immunogen
• Preparation and Storage: Store at 4 degree C for short term storage. For long term storage aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles.

Western Blot (WB)

(Lane 1: Rat Brain Tissue Lysate, Lane 2: Rat Brain Tissue Lysate)

Related Product Information for anti-PKCG antibody

Protein kinase C also known as PKC is a family of enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol or Ca2+. Hence PKC enzymes play important roles in several signal transduction cascades.

Product Categories/Family for anti-PKCG antibody

Proteases; Inhibitors; & Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 6981400
• NCBI GeneID: 24681
• NCBI GenBank Nucleotide #: NP_036760.1
• UniProt Accession #: P63319
• NCBI Official Full Name: protein kinase C gamma type
• NCBI Official Synonym Full Names: protein kinase C, gamma
• NCBI Official Symbol: Prkcg
• NCBI Official Synonym Symbols: PKC; PKCI; Prkc; Prkcc; RATPKCI
• NCBI Protein Information: protein kinase C gamma type
• UniProt Protein Name: Protein kinase C gamma type
• UniProt Gene Name: Prkcg
• UniProt Synonym Gene Names: Pkcc; Pkcg; Prkcc; PKC-gamma
• UniProt Entry Name: KPCG_RAT

NCBI Description

enriched in the neurons of the central nervous system and the spinal cord [RGD, Feb 2006]

Uniprot Description

PKCG: a calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase. Expressed in the brain and spinal cord where its localization is restricted to neurons. Several neuronal functions, including long term potentiation and depression (LTP&LTD) specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects have been associated with neurodegenerative disorder spinocerebellar ataxia-14. Plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GLUR4 and NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor MGLUR5 and phosphorylates NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43, resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress. Phosphorylates p53 and promotes p53-dependent apoptosis in response to DNA damage. Interacts with GRIA4. Interacts with CDCP1. Interacts with TP53INP1 and p53. Expressed in Purkinje cells of the cerebellar cortex.

Protein type: Kinase, protein; EC 2.7.11.13; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; AGC group; PKC family; Alpha subfamily

Cellular Component: neuron projection; perinuclear region of cytoplasm; cytoplasm; dendrite; plasma membrane; intercellular junction; cytosol; nucleus

Molecular Function: protein binding; protein kinase C activity; zinc ion binding; protein serine/threonine/tyrosine kinase activity; calcium-dependent protein kinase C activity; ATP binding; protein kinase activity

Biological Process: positive regulation of mismatch repair; protein amino acid autophosphorylation; rhythmic process; response to morphine; response to pain; regulation of circadian rhythm; synaptic transmission; learning and/or memory; chemosensory behavior; negative regulation of protein ubiquitination; negative regulation of neuron apoptosis; negative regulation of protein catabolic process; phosphorylation; regulation of response to food