Rabbit PENK Polyclonal Antibody | anti-PENK antibody

PENK Polyclonal Antibody

Cat. Num. AAA3011492

• Gene Names: PENK; PE; PENK-A
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: PENK; Polyclonal Antibody; PENK Polyclonal Antibody; Proenkephalin-A; anti-PENK antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: PENK polyclonal antibody detects endogenous levels of PENK protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 267

• Applicable Applications for anti-PENK antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200
• Immunogen: Recombinant full length Human PENK.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of PENK polyclonal antibody)

Related Product Information for anti-PENK antibody

The Proenkephalin precursor proteins are secreted proteins belonging to the opioid neuropeptide precursor family. The proenkephalin proteins are proteolytically processed to form active secreted opioid peptides which function as ligands for the kappa-type of opiod receptor. Proenkephalin A precursor contains Synenkephalin, Leu-enkephalin and Met-enkephalin processed active peptides while the Proenkephalin B precursor contains beta-neoendorphin, Dynorphin, Leumorphin, Leu-enkephalin and Rimorphin processed active peptides. beta-endorphin and Met-enkephalin are endogenous opiates while ACTH is crucial for adrenal gland stimulation to release cortisol. MSH increases Melanin production in melanocytes which leads to an increase in skin pigmentation. Leumorphin may be important in apoptosis prevention by being involved in the MAP-K and PI 3-K pathways.

NCBI and Uniprot Product Information

• NCBI GI #: 208879446
• NCBI GeneID: 5179
• NCBI Accession #: NP_001129162.1
• NCBI GenBank Nucleotide #: NP_001129162.1
• UniProt Accession #: P01210
• Molecular Weight: ~ 36kDa
• NCBI Official Full Name: proenkephalin-A preproprotein
• NCBI Official Synonym Full Names: proenkephalin
• NCBI Official Symbol: PENK
• NCBI Official Synonym Symbols: PE; PENK-A
• NCBI Protein Information: proenkephalin-A
• UniProt Protein Name: Proenkephalin-A
• Protein Family: Proenkephalin
• UniProt Gene Name: PENK
• UniProt Synonym Gene Names: OGF
• UniProt Entry Name: PENK_HUMAN

NCBI Description

This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the pentapeptide opioids Met-enkephalin and Leu-enkephalin, which are stored in synaptic vesicles, then released into the synapse where they bind to mu- and delta-opioid receptors to modulate the perception of pain. Other non-opioid cleavage products may function in distinct biological activities. [provided by RefSeq, Jul 2015]

Uniprot Description

PENK: Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum. Belongs to the opioid neuropeptide precursor family.

Protein type: Secreted; Secreted, signal peptide; Hormone

Chromosomal Location of Human Ortholog: 8q23-q24

Cellular Component: extracellular region

Molecular Function: neuropeptide hormone activity; protein binding; opioid peptide activity

Biological Process: startle response; behavioral fear response; neuropeptide signaling pathway; locomotory behavior; sensory perception of pain; signal transduction