Rabbit PDYN Polyclonal Antibody | anti-PDYN antibody

PDYN Polyclonal Antibody

Cat. Num. AAA3011359

• Gene Names: PDYN; ADCA; PENKB; SCA23
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: PDYN; Polyclonal Antibody; PDYN Polyclonal Antibody; ADCA; Alpha neoendorphin; Beta neoendorphin; Beta-neoendorphin-dynorphin; Big Dyn; Big dynorphin; Dyn; Dyn-A17; Dyn-B; Dynorphin A; Dynorphin A(1-13); Dynorphin A(1-17); Dynorphin A(1-8); Dynorphin B; Dynorphin B(1-13); Dynorphin B-29; Enkephalin B; Leu enkephalin; Leumorphin; Neoendorphin dynorphin enkephalin prepropeptide; PDYN_HUMAN; PENKB; Preprodynorphin; Preproenkephalin B; Prodynorphin; Proenkephalin B; Rimorphin; SCA23; anti-PDYN antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: PDYN polyclonal antibody detects endogenous levels of PDYN protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 254

• Applicable Applications for anti-PDYN antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200
• Immunogen: Recombinant full length Human PDYN.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot analysis of PDYN polyclonal antibody)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human lung cancer tissue using PDYN antibody at dilution of 1:100 (40x lens).)

Related Product Information for anti-PDYN antibody

The Proenkephalin precursor proteins are secreted proteins belonging to the opioid neuropeptide precursor family. The Proenkephalin proteins are proteolytically processed to form active secreted opioid peptides, which function as ligands for the ?-type of opioid receptor. The Proenkephalin A precursor contains Synenkephalin, Leu-enkephalin and Met-enkephalin processed active peptides, while the Proenkephalin B precursor contains beta-neoendorphin, Dynorphin, Leumorphin, Leu-enkephalin and rimorphin processed active peptides. beta-endorphin and Met-enkephalin are endogenous opiates, while ACTH is crucial for adrenal gland stimulation to release cortisol. MSH increases melanin production in melanocytes, which leads to an increase in skin pigmentation. Leumorphin may be important in apoptosis prevention by being involved in the MAP kinase and PI 3-kinase pathways.

NCBI and Uniprot Product Information

• NCBI GI #: 127976
• NCBI GeneID: 5173
• UniProt Accession #: P01213
• Molecular Weight: ~ 28kDa
• NCBI Official Full Name: Proenkephalin-B
• NCBI Official Synonym Full Names: prodynorphin
• NCBI Official Symbol: PDYN
• NCBI Official Synonym Symbols: ADCA; PENKB; SCA23
• NCBI Protein Information: proenkephalin-B
• UniProt Protein Name: Proenkephalin-B
• Protein Family: Proenkephalin
• UniProt Gene Name: PDYN
• UniProt Synonym Gene Names: Big Dyn; Dyn-A17; Dynorphin A; Dyn-B
• UniProt Entry Name: PDYN_HUMAN

NCBI Description

The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]

Uniprot Description

PDYN: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. Defects in PDYN are the cause of spinocerebellar ataxia type 23 (SCA23). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA23 is an adult-onset autosomal dominant form characterized by slowly progressive gait and limb ataxia, with variable additional features, including peripheral neuropathy and dysarthria. Belongs to the opioid neuropeptide precursor family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: plasma membrane; extracellular region

Molecular Function: opioid peptide activity

Biological Process: synaptic transmission; neuropeptide signaling pathway

Disease: Spinocerebellar Ataxia 23