Rabbit PDE6B Polyclonal Antibody | anti-PDE6B antibody

PDE6B Antibody

Cat. Num. AAA9611440

• Gene Names: PDE6B; rd1; PDEB; RP40; CSNB3; CSNBAD2; GMP-PDEbeta
• Reactivity: Human, Mouse; Predicted: Pig, Bovine, Horse, Sheep, Dog
• Applications: Western Blot
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: PDE6B; Polyclonal Antibody; PDE6B Antibody; 5''-cyclic phosphodiesterase subunit beta; Congenital stationary night blindness 3 autosomal dominant; CSNB 3; CSNB3; CSNBAD2; GMP PDE beta; GMP-PDE beta; PDE 6 beta; PDE 6B; PDE6B_HUMAN; PDEB; Phosphodiesterase 6B; Phosphodiesterase 6B cGMP specific rod beta; Rd 1; Rd1; Rod cGMP phosphodiesterase beta subunit; Rod cGMP specific 3' 5' cyclic phosphodiesterase beta subunit; Rod cGMP-specific 3''; RP40; anti-PDE6B antibody

• Host: Rabbit
• Reactivity: Human, Mouse; Predicted: Pig, Bovine, Horse, Sheep, Dog
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: PDE6B Antibody detects endogenous levels of PDE6B.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 854

• Applicable Applications for anti-PDE6B antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: A synthesized peptide derived from human PDE6B.
• Fragment: Fab Fragment
• Conjugate: Unconjugated
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Western Blot (WB)

(Western blot analysis of extracts from A549 cells, using PDE6B Antibody. The lane on the left was treated with blocking peptide.)

Related Product Information for anti-PDE6B antibody

Description: This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme.

Subunit Structure: Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.

Similarity: Belongs to the cyclic nucleotide phosphodiesterase family.

NCBI and Uniprot Product Information

• NCBI GI #: 105990537
• NCBI GeneID: 5158
• NCBI Accession #: NP_000274.2
• NCBI GenBank Nucleotide #: NP_000274.2
• UniProt Accession #: P35913
• Molecular Weight: Observed: 98 kDa; Predicted: 99 kDa
• NCBI Official Full Name: rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta isoform 1
• NCBI Official Synonym Full Names: phosphodiesterase 6B
• NCBI Official Symbol: PDE6B
• NCBI Official Synonym Symbols: rd1; PDEB; RP40; CSNB3; CSNBAD2; GMP-PDEbeta
• NCBI Protein Information: rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
• UniProt Protein Name: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
• Protein Family: Rod cGMP-specific 3',5'-cyclic phosphodiesterase
• UniProt Gene Name: PDE6B
• UniProt Synonym Gene Names: PDEB
• UniProt Entry Name: PDE6B_HUMAN

NCBI Description

Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]