Testing Data
Rabbit PDE6B Polyclonal Antibody | anti-PDE6B antibody
PDE6B Antibody
Gene Names
PDE6B; rd1; PDEB; RP40; CSNB3; CSNBAD2; GMP-PDEbeta
Reactivity
HumanPredicted: Mouse, Rat
Applications
ELISA, Western Blot, Immunohistochemistry
Synonyms
PDE6B; Polyclonal Antibody; PDE6B Antibody; anti-PDE6B antibody
Host
Rabbit
Reactivity
Human
Predicted: Mouse, Rat
Predicted: Mouse, Rat
Clonality
Polyclonal
Form/Format
Purified by protein A column containing 0.02% NaN3
Sequence Length
640
Applicable Applications for anti-PDE6B antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
ELISA: 1:20,000-1:80,000
WB: 1:500-1:1,000
IHC: 1:100-1:500
WB: 1:500-1:1,000
IHC: 1:100-1:500
Preparation and Storage
Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at-20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.
Testing Data
Testing Data
Testing Data
Testing Data
Related Product Information for anti-PDE6B antibody
Rabbit polyclonal PDE6B (1) antibody was raised against a recombinate human PDE6B protein 566-848aa (BC000249).
Product Categories/Family for anti-PDE6B antibody
References
(1) Booij, J.C., Bakker, A., Kulumbetova, J., et al. Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip. Ophthalmology 118 (1), 160-167 (2011).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
66,494 Da
NCBI Official Full Name
phosphodiesterase 6B, cGMP-specific, rod, beta (congenital stationary night blindness 3, autosomal dominant), isoform CRA_b
NCBI Official Synonym Full Names
phosphodiesterase 6B
NCBI Official Symbol
PDE6B
NCBI Official Synonym Symbols
rd1; PDEB; RP40; CSNB3; CSNBAD2; GMP-PDEbeta
NCBI Protein Information
rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
UniProt Protein Name
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
Protein Family
UniProt Gene Name
PDE6B
UniProt Synonym Gene Names
PDEB; GMP-PDE beta
NCBI Description
Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
Uniprot Description
This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme.
Research Articles on PDE6B
Similar Products
Product Notes
The PDE6B pde6b (Catalog #AAA854087) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PDE6B Antibody reacts with Human Predicted: Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PDE6B can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). ELISA: 1:20,000-1:80,000 WB: 1:500-1:1,000 IHC: 1:100-1:500. Researchers should empirically determine the suitability of the PDE6B pde6b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PDE6B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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