Rabbit PDE6B Polyclonal Antibody | anti-PDE6B antibody

PDE6B Polyclonal Antibody

Cat. Num. AAA9433896

• Gene Names: PDE6B; rd1; PDEB; RP40; CSNB3; CSNBAD2; GMP-PDEbeta
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: Affinity purification
• Synonyms: PDE6B; Polyclonal Antibody; PDE6B Polyclonal Antibody; CSNB3; CSNBAD2; PDEB; RP40; rd1; GMP-PDEbeta; phosphodiesterase 6B; anti-PDE6B antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Form/Format: PBS with 50% glycerol, pH7.4
• Sequence Length: 853

• Applicable Applications for anti-PDE6B antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:100; IF: 1:50-1:100
• Immunogen: Recombinant fusion protein of human PDE6B (NP_001138763.1).
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using PDE6B antibody.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded rat retina using PDE6B antibody.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded mouse retina using PDE6B antibody.)

Related Product Information for anti-PDE6B antibody

Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-PDE6B antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 223718037
• NCBI GeneID: 5158
• NCBI Accession #: NP_001138763.1
• NCBI GenBank Nucleotide #: NP_001138763.1
• UniProt Accession #: P35913
• Molecular Weight: 98kDa
• NCBI Official Full Name: rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta isoform 2
• NCBI Official Synonym Full Names: phosphodiesterase 6B
• NCBI Official Symbol: PDE6B
• NCBI Official Synonym Symbols: rd1; PDEB; RP40; CSNB3; CSNBAD2; GMP-PDEbeta
• NCBI Protein Information: rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
• UniProt Protein Name: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
• Protein Family: Rod cGMP-specific 3',5'-cyclic phosphodiesterase
• UniProt Gene Name: PDE6B
• UniProt Synonym Gene Names: PDEB
• UniProt Entry Name: PDE6B_HUMAN

NCBI Description

Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]