Rabbit PDE3A Polyclonal Antibody | anti-PDE3A antibody

Rabbit Polyclonal to Human PDE3A

Cat. Num. AAA240127

• Gene Names: PDE3A; CGI-PDE; CGI-PDE A; CGI-PDE-A
• Reactivity: Gibbon, Horse, Human, Monkey, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: PDE3A; Polyclonal Antibody; Rabbit Polyclonal to Human PDE3A; Anti-PDE3A Antibody (Internal) IHC-plus; CGI-PDE-A; HcGIP2; Phosphodiesterase 3a; Phosphodiesterase isoform 3a; CGI-PDE; CGI-PDE A; CGIP2; HPDE-3A; Phosphodiesterase type 3A; Human PDE3A; anti-PDE3A antibody

• Host: Rabbit
• Reactivity: Gibbon, Horse, Human, Monkey, Mouse, Rat
• Clonality: Polyclonal
• Specificity: Human PDE3A. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 1141

• Applicable Applications for anti-PDE3A antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (20 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
• Target Species: Human
• Immunogen Description: Synthetic 17 amino acid peptide from internal region of human PDE3A. Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Mouse, Rat, Horse, Opossum (100%); Chicken (88%).
• Immunogen Type: Synthetic peptide
• Immunogen: PDE3A antibody was raised against synthetic 17 amino acid peptide from internal region of human PDE3A. Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Mouse, Rat, Horse, Opossum (100%); Chicken (88%).
• Antigen Modification: Internal
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-PDE3A antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-PDE3A antibody

Phosphodiesterase 3A is a cGMP inhibited, cAMP/cGMP dual-specific phosphodiesterase. PDE3A has been implicated in male erectile dysfunction, mammalian oocyte maturation, platelet function, vascular smooth muscle function, and salivary gland tumors. Three alternatively spliced transcripts have been reported.

Product Categories/Family for anti-PDE3A antibody

Family: Phosphodiesterase; Subfamily: PDE - cAMP/cGMP dual-specific; cGMP-inhibited

NCBI and Uniprot Product Information

• NCBI GI #: 70608155
• NCBI GeneID: 5139
• NCBI Accession #: NP_000912.3
• NCBI GenBank Nucleotide #: NM_000921.4
• UniProt Accession #: Q14432; O60865; Q13348; Q17RD1
• Molecular Weight: 124,979 Da
• NCBI Official Full Name: cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform 1
• NCBI Official Synonym Full Names: phosphodiesterase 3A, cGMP-inhibited
• NCBI Official Symbol: PDE3A
• NCBI Official Synonym Symbols: CGI-PDE; CGI-PDE A; CGI-PDE-A
• NCBI Protein Information: cGMP-inhibited 3',5'-cyclic phosphodiesterase A; cyclic GMP-inhibited phosphodiesterase A; cAMP phosphodiesterase, myocardial cGMP-inhibited
• UniProt Protein Name: cGMP-inhibited 3',5'-cyclic phosphodiesterase A
• Protein Family: cGMP-inhibited 3',5'-cyclic phosphodiesterase
• UniProt Gene Name: PDE3A
• UniProt Synonym Gene Names: CGI-PDE A
• UniProt Entry Name: PDE3A_HUMAN

NCBI Description

This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

Uniprot Description

PDE3A: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Inhibited by cGMP. Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily.

Protein type: EC 3.1.4.17; Phosphodiesterase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: 12p12

Cellular Component: integral to membrane; cytosol

Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; metal ion binding; cAMP binding

Biological Process: response to drug; diterpenoid metabolic process; cAMP-mediated signaling; response to cAMP; cGMP-mediated signaling; cAMP catabolic process; regulation of meiosis; negative regulation of vascular permeability; lipid metabolic process; blood coagulation; oocyte maturation; positive regulation of vascular permeability; negative regulation of apoptosis

Disease: Hypertension And Brachydactyly Syndrome