Western Blot (WB)
(Western blot analysis of Mouse brain cell lysates showing detection of RSK1 protein using Rabbit Anti-RSK1 Polyclonal Antibody (SPC-147). Primary Antibody: Rabbit Anti-RSK1 Polyclonal Antibody (SPC-147) at 1:1000. P90 RSK1 immuno-precipitated from the mouse brain extract (left) and immuno-precipitated negative control (right).)
Rabbit p90 RSK1 Polyclonal Antibody | anti-RPS6KA1 antibody
p90 RSK1 Antibody: Alkaline Phosphatase
Gene Names
RPS6KA1; RSK; HU-1; RSK1; MAPKAPK1A
Reactivity
Human, Mouse, Rat, Bovine
Applications
Western Blot, Immunoprecipitation, ELISA
Synonyms
p90 RSK1; Polyclonal Antibody; p90 RSK1 Antibody: Alkaline Phosphatase; RSK1 p90; HU1; MAPKAP; p90rsk; p90S6K; RSK1; RSK 1 p90; anti-RPS6KA1 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat, Bovine
Clonality
Polyclonal
Form/Format
Affinity Purified
Concentration
250ug/mL (varies by lot)
Sequence Length
735
Applicable Applications for anti-RPS6KA1 antibody
Western Blot (WB), Immunoprecipitation (IP), ELISA (EIA)
Application Notes
1ug/mL (WB)
Conjugate
Alkaline Phosphatase
Storage Buffer
TBS, 50% glycerol, 0.09% sodium azide
Preparation and Storage
-20 degree C
Western Blot (WB)
(Western blot analysis of Mouse brain cell lysates showing detection of RSK1 protein using Rabbit Anti-RSK1 Polyclonal Antibody (SPC-147). Primary Antibody: Rabbit Anti-RSK1 Polyclonal Antibody (SPC-147) at 1:1000. P90 RSK1 immuno-precipitated from the mouse brain extract (left) and immuno-precipitated negative control (right).)
Western Blot (WB)
(Western blot analysis of Mouse brain cell lysates showing detection of RSK1 protein using Rabbit Anti-RSK1 Polyclonal Antibody (SPC-147). Primary Antibody: Rabbit Anti-RSK1 Polyclonal Antibody (SPC-147) at 1:1000. P90 RSK1 immuno-precipitated from the mouse brain extract (left) and immuno-precipitated negative control (right).)
Related Product Information for anti-RPS6KA1 antibody
Background Info: Detects a ~90kDa protein corresponding to the molecular mass of p90 RSK1 on SDS PAGE immunoblots.
Scientific Background: The p90 ribosomal S6 kinase (Rsk) family comprises four mammalian serine/threonine kinases (Rsk1-4). In the past, S6K1 and S6K2 were thought to be the predominant operating S6 kinases, however RSK 1 and 2 have been shown to phosphorylate S6 in response to the ERK pathway, or otherwise known as the extra cellular signal-regulated kinases pathway. RSK 1 in particular is very multifunctional as it participates in nuclear signaling, regulates nuclear factors, regulates several transcription factors like c-Fos, and interacts with the transcriptional coactivator CREB-binding protein. As a result, RSK1 seems to have an important role in cellular growth control and proliferation. (1-5).
Scientific Background: The p90 ribosomal S6 kinase (Rsk) family comprises four mammalian serine/threonine kinases (Rsk1-4). In the past, S6K1 and S6K2 were thought to be the predominant operating S6 kinases, however RSK 1 and 2 have been shown to phosphorylate S6 in response to the ERK pathway, or otherwise known as the extra cellular signal-regulated kinases pathway. RSK 1 in particular is very multifunctional as it participates in nuclear signaling, regulates nuclear factors, regulates several transcription factors like c-Fos, and interacts with the transcriptional coactivator CREB-binding protein. As a result, RSK1 seems to have an important role in cellular growth control and proliferation. (1-5).
Product Categories/Family for anti-RPS6KA1 antibody
References
1. Roux, P. (2007). UCSD-Nature Molecule Pages. 2. Fro¨din, M. and Gammeltoft, S. (1999) Mol. Cell. Endocrinol. 151: 65-77. 3. Merienne, K. et al. (1998) J. Med. Genet. 35: 890-894. 4. De Cesare, D. et al. (1998) Proc. Natl. Acad. Sci. 95: 12202-12207. 5. Joel, P. B. et al. (1998) Mol. Cell. Biol. 18: 1978-1984.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
72,698 Da
NCBI Official Full Name
ribosomal protein S6 kinase alpha-1 isoform a
NCBI Official Synonym Full Names
ribosomal protein S6 kinase, 90kDa, polypeptide 1
NCBI Official Symbol
RPS6KA1
NCBI Official Synonym Symbols
RSK; HU-1; RSK1; MAPKAPK1A
NCBI Protein Information
ribosomal protein S6 kinase alpha-1; RSK-1; p90S6K; p90RSK1; p90-RSK 1; MAPKAPK-1a; S6K-alpha 1; S6K-alpha-1; MAPKAP kinase 1a; ribosomal S6 kinase 1; MAPK-activated protein kinase 1a; ribosomal protein S6 kinase alpha 1; 90 kDa ribosomal protein S6 kinase 1; MAP kinase-activated protein kinase 1a; dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1)
UniProt Protein Name
Ribosomal protein S6 kinase alpha-1
Protein Family
UniProt Gene Name
RPS6KA1
UniProt Synonym Gene Names
MAPKAPK1A; RSK1; S6K-alpha-1; p90-RSK 1; p90RSK1; p90S6K; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; RSK-1
UniProt Entry Name
KS6A1_HUMAN
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Product Notes
The RPS6KA1 rps6ka1 (Catalog #AAA805882) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The p90 RSK1 Antibody: Alkaline Phosphatase reacts with Human, Mouse, Rat, Bovine and may cross-react with other species as described in the data sheet. AAA Biotech's p90 RSK1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP), ELISA (EIA). 1ug/mL (WB). Researchers should empirically determine the suitability of the RPS6KA1 rps6ka1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "p90 RSK1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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