Rabbit P2RY12 / P2Y12 Polyclonal Antibody | anti-P2RY12 antibody

Rabbit Polyclonal to Human P2RY12 / P2Y12

Cat. Num. AAA244421

• Gene Names: P2RY12; HORK3; P2Y12; ADPG-R; BDPLT8; SP1999; P2T(AC); P2Y(AC); P2Y(12)R; P2Y(ADP); P2Y(cyc)
• Reactivity: Gibbon, Dog, Gorilla, Horse, Human, Monkey, Rabbit; Predicted Reactivity: Bat, Pig (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: P2RY12 / P2Y12; Polyclonal Antibody; Rabbit Polyclonal to Human P2RY12 / P2Y12; Anti-P2RY12 / P2Y12 Antibody (Extracellular Domain) IHC-plus; P2RY12; ADP-glucose receptor; ADPG-R; p2Y(12)R; p2Y(ADP); p2T(AC); p2Y12; Platelet ADP receptor; SP1999; p2RY12; p2Y purinoceptor 12; Purinergic receptor P2RY12; BDPLT8; Gi-coupled ADP receptor HORK3; HORK3; p2Y(AC); p2Y(cyc); p2Y12 platelet ADP receptor; Human P2RY12; P2Y12; anti-P2RY12 antibody

• Host: Rabbit
• Reactivity: Gibbon, Dog, Gorilla, Horse, Human, Monkey, Rabbit; Predicted Reactivity: Bat, Pig (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human P2RY12 / P2Y12. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except CACNA1F (56%).
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 0.8 mg/ml (varies by lot)
• Sequence Length: 342

• Applicable Applications for anti-P2RY12 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (10 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 16 amino acid peptide from 2nd extracellular domain of human P2RY12 / P2Y12. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Panda, Dog, Horse, Rabbit (100%); Bat, Pig, Platypus (94%); Mouse.
• Immunogen Type: Synthetic peptide
• Immunogen: P2RY12 / P2Y12 antibody was raised against synthetic 16 amino acid peptide from 2nd extracellular domain of human P2RY12 / P2Y12. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Panda, Dog, Horse, Rabbit (100%); Bat, Pig, Platypus (94%); Mouse, Hamster, Bovine, Opossum (88%); Rat, Elephant (81%).
• Antigen Modification: Extracellular Domain
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-P2RY12 / P2Y12 antibody IHC of human bone marrow, megakaryocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-P2RY12 antibody

P2Y12 is a Purinergic Receptor essential for the aggregation of blood platelets. There is evidence that mutations in P2Y12 cause a bleeding disorder, suggesting that knowledge of the P2Y12 receptor could advance the development of antiplatelet agents to treat cardiovascular diseases.

Product Categories/Family for anti-P2RY12 antibody

Family: GPCR; Subfamily: Purinergic

NCBI and Uniprot Product Information

• NCBI GI #: 12232483
• NCBI GeneID: 64805
• NCBI Accession #: NP_073625.1
• NCBI GenBank Nucleotide #: NM_022788.4
• UniProt Accession #: Q9H244; Q546J7; D3DNJ5
• Molecular Weight: 39,439 Da
• NCBI Official Full Name: P2Y purinoceptor 12
• NCBI Official Synonym Full Names: purinergic receptor P2Y, G-protein coupled, 12
• NCBI Official Symbol: P2RY12
• NCBI Official Synonym Symbols: HORK3; P2Y12; ADPG-R; BDPLT8; SP1999; P2T(AC); P2Y(AC); P2Y(12)R; P2Y(ADP); P2Y(cyc)
• NCBI Protein Information: P2Y purinoceptor 12; ADP-glucose receptor; purinergic receptor P2RY12; P2Y12 platelet ADP receptor; Gi-coupled ADP receptor HORK3; G-protein coupled receptor SP1999; putative G-protein coupled receptor
• UniProt Protein Name: P2Y purinoceptor 12
• Protein Family: P2Y purinoceptor
• UniProt Gene Name: P2RY12
• UniProt Synonym Gene Names: HORK3; P2Y12; ADPG-R; P2Y(ADP)
• UniProt Entry Name: P2Y12_HUMAN

NCBI Description

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Uniprot Description

P2Y12: Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelets aggregation. Defects in P2RY12 are the cause of bleeding disorder platelet-type 8 (BDPLT8). A condition characterized by mild to moderate mucocutaneous bleeding, and excessive bleeding after surgery or trauma. The defect is due to severe impairment of platelet response to ADP resulting in defective platelet aggregation. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3q25.1

Cellular Component: cell surface; mitochondrion; integral to plasma membrane; basal plasma membrane; plasma membrane; intrinsic to membrane; caveola; external side of plasma membrane

Molecular Function: guanyl-nucleotide exchange factor activity; adenosine receptor activity, G-protein coupled; platelet ADP receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; platelet activation; negative regulation of cell differentiation; cell projection organization and biogenesis; hemostasis; protein kinase B signaling cascade; positive regulation of ion transport; G-protein signaling, adenylate cyclase inhibiting pathway; regulation of calcium ion transport; blood coagulation; adenosine receptor signaling pathway; positive regulation of GTPase activity

Disease: Bleeding Disorder, Platelet-type, 8