Western Blot (WB)
P2Y12 positive control
P2Y12 Positive Control
Western Blot (WB)
Western Blot (WB)
Serves as a receptor for ADP and ATP that is coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. It is necessary for platelet aggregation and blood coagulation.
NCBI and Uniprot Product Information
NCBI Description
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Uniprot Description
P2Y12: Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelets aggregation. Defects in P2RY12 are the cause of bleeding disorder platelet-type 8 (BDPLT8). A condition characterized by mild to moderate mucocutaneous bleeding, and excessive bleeding after surgery or trauma. The defect is due to severe impairment of platelet response to ADP resulting in defective platelet aggregation. Belongs to the G-protein coupled receptor 1 family.
Protein type: Membrane protein, multi-pass; GPCR, family 1; Mitochondrial; Receptor, GPCR; Membrane protein, integral
Chromosomal Location of Human Ortholog: 3q25.1
Cellular Component: basal plasma membrane; caveola; cell surface; external side of plasma membrane; integral to plasma membrane; intrinsic to membrane; mitochondrion; plasma membrane
Molecular Function: adenosine receptor activity, G-protein coupled; guanyl-nucleotide exchange factor activity; platelet ADP receptor activity
Biological Process: adenosine receptor signaling pathway; G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; glial cell migration; hemostasis; negative regulation of cell differentiation; positive regulation of GTPase activity; positive regulation of ion transport; protein kinase B signaling cascade; regulation of calcium ion transport; substrate-bound cell migration, cell extension
Disease: Bleeding Disorder, Platelet-type, 8
Research Articles on P2Y12
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Product Notes
The P2Y12 p2ry12 (Catalog #AAA543017) is a Positive Control and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's P2Y12 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:500. Researchers should empirically determine the suitability of the P2Y12 p2ry12 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "P2Y12, Positive Control" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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